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Proteintech
TNPO2 Polyclonal Antibody
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Product Details
17831-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TNPO2 Fusion Protein Ag12229 (1-350 aa encoded by BC072420)
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MDWQPDEQG LQQVLQLLKD SQSPNTATQR IVQDKLKQLN QFPDFNNYLI FVLTRLKSED EPTRSLSGLI LKNNVKAHYQ SFPPPVADFI KQECLNNIGD ASSLIRATIG ILITTIASKG ELQMWPELLP QLCNLLNSED YNTCEGAFGA LQKICEDSSE LLDSDALNRP LNIMIPKFLQ FFKHCSPKIR SHAIACVNQF IMDRAQALMD NIDTFIEHLF ALAVDDDPEV RKNVCRALVM LLEVRIDRLI PHMHSIIQYM LQRTQDHDEN VALEACEFWL TLAEQPICKE VLASHLVQLI PILVNGMKYS EIDIILLKGD VEEDEAVPDS EQDIKPRFHK SRTVTLPHEA E (1-350 aa encoded by BC072420)
Target Information
Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: importin 3; karyopherin (importin) beta 2b; karyopherin beta 2b, transportin; Karyopherin beta-2b; transportin 2 (importin 3, karyopherin beta 2b); Transportin-2
Gene Aliases: 1110034O24Rik; AA414969; AI464345; AI852433; IPO3; Knpb2b; KPNB2B; TNPO2; TRN2
UniProt ID: (Human) O14787, (Mouse) Q99LG2
Entrez Gene ID: (Human) 30000, (Mouse) 212999, (Rat) 304670
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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