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Invitrogen
TNPO3 Polyclonal Antibody
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Product Details
PA5-58834
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TNPO3. Recombinant protein control fragment (Product #RP-92622).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2648795
Product Specific Information
Immunogen sequence: VRCVGKGSAA LLQPLVTQMV NVYHVHQHSC FLYLGSILVD EYGMEEGCRQ GLLDMLQALC IPTFQLLEQQ NGLQNHPDTV DDLFRLATRF IQRSPVTLLR SQVVIPILQW AIASTTLDH
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins. Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated. More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment. At least three isoforms of TNPO3 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Imp12; importin 12; Importin-12; limb girdle muscular dystrophy 1F (autosomal dominant); Transportin-3; Transportin-SR; TRN-SR
Gene Aliases: IPO12; LGMD1F; MTR10A; TNPO3; TRN-SR; TRN-SR2; TRNSR
UniProt ID: (Human) Q9Y5L0
Entrez Gene ID: (Human) 23534
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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