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Proteintech
TOB2 Polyclonal Antibody
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Product Details
13607-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TOB2 Fusion Protein Ag4491 (1-344 aa encoded by BC038957)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MQLEIKVAL NFIISYLYNK LPRRRADLFG EELERLLKKK YEGHWYPEKP LKGSGFRCVH IGEMVDPVVE LAAKRSGLAV EDVRANVPEE LSVWIDPFEV SYQIGEKGAV KVLYLDDSEG CGAPELDKEI KSSFNPDAQV FVPIGSQDSS LSNSPSPSFG QSPSPTFIPR SAQPITFTTA SFAATKFGST KMKKGGGAAS GGGVASSGAG GQQPPQQPRM ARSPTNSLLK HKSLSLSMHS LNFITANPAP QSQLSPNAKE FVYNGGGSPS LFFDAADGQG SGTPGPFGGS GAGTCNSSSF DMAQVFGGGA NSLFLEKTPF VEGLSYNLNT MQYPSQQFQP VVLAN (1-344 aa encoded by BC038957)
Target Information
TOB2 is a 344 amino acid rich novel member of the Tob/BTG1 anti-proliferative family of proteins characterized by similarities in their N-terminal BTG/Tob homology domains. This anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases and is involved in cell cycle regulation through interaction with Caf1, a component of the CCR4 transcription factor complex that associates with cyclin-dependent kinases. Recent reports suggest that TOB2 plays important roles in spermatogenesis, embryonic dorsoventral patterning, osteogenesis, T-cell activation, learning and memory and acts primarily as a transcriptional repressor in several signaling pathways. TOB2, a signaling protein, may participate in transcriptional regulation of several genes. It is a regulatory protein ubiquitously expressed in most of the tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Protein Tob2; Protein Tob4; Transducer of erbB-2 2
Gene Aliases: 2900090N22Rik; 4930545K18Rik; APRO5; AV071822; KIAA1663; mKIAA1663; TOB2; TOB4; TOBL; TROB2
UniProt ID: (Human) Q14106, (Mouse) Q9JM55
Entrez Gene ID: (Human) 10766, (Rat) 315159, (Mouse) 57259
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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