Proteintech

TOM70 Polyclonal Antibody

TOM70 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 23

TOM70 Antibody (14528-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using TOM70 antibody (Product # 14528-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), CL594-Phalloidin (red).

TOM70 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

TOM70 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

14528-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 46 publications 46 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 11 publications 11 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

View 3 publications 3 publications

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TOM70 Fusion Protein Ag6027 (245-608 aa encoded by BC052994)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.26 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: KNREPLMPS PQFIKSYFSS FTDDIISQPM LKGEKSDEDK DKEGEALEVK ENSGYLKAKQ YMEEENYDKI ISECSKEIDA EGKYMAEALL LRATFYLLIG NANAAKPDLD KVISLKEANV KLRANALIKR GSMYMQQQQP LLSTQDFNMA ADIDPQNADV YHHRGQLKIL LDQVEEAVAD FDECIRLRPE SALAQAQKCF ALYRQAYTGN NSSQIQAAMK GFEEVIKKFP RCAEGYALYA QALTDQQQFG KADEMYDKCI DLEPDNATTY VHKGLLQLQW KQDLDRGLEL ISKAIEIDNK CDFAYETMGT IEVQRGNMEK AIDMFNKAIN LAKSEMEMAH LYSLCDAAHA QTEVAKKYGL KPPTL (245-608 aa encoded by BC052994)

Target Information

Functional mitochondria require up to 1000 proteins to function properly, with 99% synthesized as precursors in the cytoplasm and transported into the mitochondria with the aid of cytosolic chaperones and mitochondrial translocators (import components). Proteins to be imported are chaperoned to the mitochondria by the cytosolic heat shock protein (cHSP70) and are immediately pursued by Translocators of the Outer Membrane (TOMs), followed by transient interactions of the unfolded proteins with Translocators of the Inner Membrane (TIMs). TOMM70A is ubiquitously expressed in human tissues and localizes in the mitochondria. TOMM70A could play a significant role in the import of nuclear-encoded mitochondrial proteins with internal targeting sites such as ADP/ATP carriers and the uncoupling proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Coxsackievirus B Escapes the Infected Cell in Ejected Mitophagosomes.

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Mitophagy and mitochondrial biogenesis in atrial tissue of patients undergoing heart surgery with cardiopulmonary bypass.

JCI insight

Andres AM,Tucker KC,Thomas A,Taylor DJ,Sengstock D,Jahania SM,Dabir R,Pourpirali S,Brown JA,Westbrook DG,Ballinger SW,Mentzer RM,Gottlieb RA

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Sin J,Andres AM,Taylor DJ,Weston T,Hiraumi Y,Stotland A,Kim BJ,Huang C,Doran KS,Gottlieb RA

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Sin J,Andres AM,Taylor DJ,Weston T,Hiraumi Y,Stotland A,Kim BJ,Huang C,Doran KS,Gottlieb RA

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Autophagy

Sin J,Andres AM,Taylor DJ,Weston T,Hiraumi Y,Stotland A,Kim BJ,Huang C,Doran KS,Gottlieb RA

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Autophagy

Sin J,Andres AM,Taylor DJ,Weston T,Hiraumi Y,Stotland A,Kim BJ,Huang C,Doran KS,Gottlieb RA

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Thu Dec 01 00:00:00 UTC 2016

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Journal of medical genetics

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Thu Dec 01 00:00:00 UTC 2016

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Xu S,Cherok E,Das S,Li S,Roelofs BA,Ge SX,Polster BM,Boyman L,Lederer WJ,Wang C,Karbowski M

Fri Jan 15 00:00:00 UTC 2016

Mitochondrial E3 ubiquitin ligase MARCH5 controls mitochondrial fission and cell sensitivity to stress-induced apoptosis through regulation of MiD49 protein.

Molecular biology of the cell

Xu S,Cherok E,Das S,Li S,Roelofs BA,Ge SX,Polster BM,Boyman L,Lederer WJ,Wang C,Karbowski M

Fri Jan 15 00:00:00 UTC 2016

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eLife

Kang Y,Baker MJ,Liem M,Louber J,McKenzie M,Atukorala I,Ang CS,Keerthikumar S,Mathivanan S,Stojanovski D

Wed Aug 24 00:00:00 UTC 2016

Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability.

eLife

Kang Y,Baker MJ,Liem M,Louber J,McKenzie M,Atukorala I,Ang CS,Keerthikumar S,Mathivanan S,Stojanovski D

Wed Aug 24 00:00:00 UTC 2016

Presequence-Independent Mitochondrial Import of DNA Ligase Facilitates Establishment of Cell Lines with Reduced mtDNA Copy Number.

PloS one

Spadafora D,Kozhukhar N,Alexeyev MF

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Presequence-Independent Mitochondrial Import of DNA Ligase Facilitates Establishment of Cell Lines with Reduced mtDNA Copy Number.

PloS one

Spadafora D,Kozhukhar N,Alexeyev MF

Mon Aug 08 00:00:00 UTC 2016

Directed evolution of APEX2 for electron microscopy and proximity labeling.

Nature methods

Lam SS,Martell JD,Kamer KJ,Deerinck TJ,Ellisman MH,Mootha VK,Ting AY

Thu Jan 01 00:00:00 UTC 2015

Directed evolution of APEX2 for electron microscopy and proximity labeling.

Nature methods

Lam SS,Martell JD,Kamer KJ,Deerinck TJ,Ellisman MH,Mootha VK,Ting AY

Thu Jan 01 00:00:00 UTC 2015

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.

EMBO reports

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Sat Aug 01 00:00:00 UTC 2015

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.

EMBO reports

Kazlauskaite A,Martínez-Torres RJ,Wilkie S,Kumar A,Peltier J,Gonzalez A,Johnson C,Zhang J,Hope AG,Peggie M,Trost M,van Aalten DM,Alessi DR,Prescott AR,Knebel A,Walden H,Muqit MM

Sat Aug 01 00:00:00 UTC 2015

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy.

Nature

Bingol B,Tea JS,Phu L,Reichelt M,Bakalarski CE,Song Q,Foreman O,Kirkpatrick DS,Sheng M

Thu Jun 19 00:00:00 UTC 2014

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy.

Nature

Bingol B,Tea JS,Phu L,Reichelt M,Bakalarski CE,Song Q,Foreman O,Kirkpatrick DS,Sheng M

Thu Jun 19 00:00:00 UTC 2014

A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently.

Journal of cell science

Fiesel FC,Moussaud-Lamodière EL,Ando M,Springer W

Fri Aug 15 00:00:00 UTC 2014

A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently.

Journal of cell science

Fiesel FC,Moussaud-Lamodière EL,Ando M,Springer W

Fri Aug 15 00:00:00 UTC 2014

The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway.

Cell death & disease

Xu R,Hu Q,Ma Q,Liu C,Wang G

Thu Aug 14 00:00:00 UTC 2014

The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway.

Cell death & disease

Xu R,Hu Q,Ma Q,Liu C,Wang G

Thu Aug 14 00:00:00 UTC 2014

The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway.

Cell death & disease

Xu R,Hu Q,Ma Q,Liu C,Wang G

Thu Aug 14 00:00:00 UTC 2014

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.

Nature

Sarraf SA,Raman M,Guarani-Pereira V,Sowa ME,Huttlin EL,Gygi SP,Harper JW

Thu Apr 18 00:00:00 UTC 2013

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.

Nature

Sarraf SA,Raman M,Guarani-Pereira V,Sowa ME,Huttlin EL,Gygi SP,Harper JW

Thu Apr 18 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: FLJ90470; Mitochondrial import receptor subunit TOM70; Mitochondrial precursor proteins import receptor; Translocase of outer membrane 70 kDa subunit; translocase of outer mitochondrial membrane 70 homolog A; Translocase of outer mitochondrial membrane protein 70

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Gene Aliases: 2610044B22Rik; D16Ium22; D16Ium22e; D16Wsu109e; KIAA0719; mKIAA0719; TOM70; TOMM70; TOMM70A

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UniProt ID: (Human) O94826, (Mouse) Q9CZW5, (Rat) Q75Q39

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Entrez Gene ID: (Human) 9868, (Mouse) 28185, (Rat) 304017

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Function(s)

protein binding protein transmembrane transporter activity

Process(es)

protein targeting to mitochondrion macroautophagy protein transmembrane transport protein transport

Performance Guarantee

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TOM70 Polyclonal Antibody

TOM70 Antibody (14528-1-AP) in ICC/IF

Product Details

14528-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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