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Proteintech
TOMM22 Monoclonal Antibody (1C2B11)
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Product Details
66562-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1C2B11
Immunogen
TOMM22 Fusion Protein Ag1797 (1-142 aa encoded by BC009363)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
66562-1-Ig recognizes a22 kDa protein that is larger than the calculated MW of 15 kDa.
Immunogen sequence: MAAAVAAAG AGEPQSPDEL LPKGDAEKPE EELEEDDDEE LDETLSERLW GLTEMFPERV RSAAGATFDL SLFVAQKMYR FSRAALWIGT TSFMILVLPV VFETEKLQME QQQQLQQRQI LLGPNTGLSG GMPGALPSLP GKI (1-142 aa encoded by BC009363)
Target Information
Tom22 has a negatively charged N-terminal region exposed to the cytosol, a putative transmembrane region, and a C-terminal intermembrane space region with little negative charge. The following functions can be assigned to the three domains of Tom22: the cytosolic N-terminal domain plays a dual role, specifically important for presequence binding; the intermembrane space domain provides a trans binding site for presequences, and the single membrane anchor of Tom22 is crucial for the integrity of the GIP (general import gene) complex. The TOM complex of mammalian mitochondria resembles the fungal Tom complex, but is distinct from the plant TOM system. Thus, while unique components of the mammalian mitochondrial import system have been identified (e. g. TOM34 and metaxin), Tom22, and Tom37 have not been identified in plant mitochondria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 1C9-2; hTom22; Mitochondrial import receptor subunit TOM22 homolog; mitochondrial import receptor Tom22; Translocase of outer membrane 22 kDa subunit homolog; translocase of outer mitochondrial membrane 22 homolog
Gene Aliases: 1C9-2; MST065; MSTP065; TOM22; TOMM22
UniProt ID: (Human) Q9NS69
Entrez Gene ID: (Human) 56993
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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