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Invitrogen
TOMM22 Recombinant Rabbit Monoclonal Antibody (6R1L7)
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FIGURE: 1 / 4
TOMM22 Antibody (MA5-38197) in IHC (P)
Immunohistochemistry analysis of TOMM22 in paraffin-embedded human colon. Samples were incubated with TOMM22 Monoclonal antibody (Product # MA5-38197) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Product Details
MA5-38197
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
6R1L7
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TOMM22 (Q9NS69)
Conjugate
Form
Liquid
Concentration
0.41 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2898114
Product Specific Information
Positive Samples: HeLa, HepG2, K-562, Mouse brain, Mouse spleen, Rat lung, Rat brain
Immunogen sequence: MAAAVAAAGA GEPQSPDELL PKGDAEKPEE ELEEDDDEEL DETLSERLWG LTEMFPERVR SAAGATFDLS LFVAQKMYRF SRAALWIGTT SFMILVLPVV
Target Information
Tom22 has a negatively charged N-terminal region exposed to the cytosol, a putative transmembrane region, and a C-terminal intermembrane space region with little negative charge. The following functions can be assigned to the three domains of Tom22: the cytosolic N-terminal domain plays a dual role, specifically important for presequence binding; the intermembrane space domain provides a trans binding site for presequences, and the single membrane anchor of Tom22 is crucial for the integrity of the GIP (general import gene) complex. The TOM complex of mammalian mitochondria resembles the fungal Tom complex, but is distinct from the plant TOM system. Thus, while unique components of the mammalian mitochondrial import system have been identified (e. g. TOM34 and metaxin), Tom22, and Tom37 have not been identified in plant mitochondria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 1C9-2; hTom22; Mitochondrial import receptor subunit TOM22 homolog; mitochondrial import receptor Tom22; rTOM22; Translocase of outer membrane 22 kDa subunit homolog; translocase of outer mitochondrial membrane 22 homolog
Gene Aliases: 1C9-2; 2310047D01; MST065; MSTP065; rTOM22; TOM22; TOMM22
UniProt ID: (Human) Q9NS69, (Rat) Q75Q41, (Mouse) Q9CPQ3
Entrez Gene ID: (Human) 56993, (Rat) 300075, (Mouse) 223696
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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