Product References
Replication-associated formation and repair of human topoisomerase IIIα cleavage complexes.
Nature communications
Saha LK,Saha S,Yang X,Huang SN,Sun Y,Jo U,Pommier Y
Thu Apr 06 00:00:00 UTC 2023
Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability.
EMBO molecular medicine
Erdinc D,Rodríguez-Luis A,Fassad MR,Mackenzie S,Watson CM,Valenzuela S,Xie X,Menger KE,Sergeant K,Craig K,Hopton S,Falkous G,Poulton J,Garcia-Moreno H,Giunti P,de Moura Aschoff CA,Morales Saute JA,Kirby AJ,Toro C,Wolfe L,Novacic D,Greenbaum L,Eliyahu A,Barel O,Anikster Y,McFarland R,Gorman GS,Schaefer AM,Gustafsson CM,Taylor RW,Falkenberg M,Nicholls TJ
Mon May 08 00:00:00 UTC 2023
Resolution of sequence divergence for repeat-mediated deletions shows a polarity that is mediated by MLH1.
Nucleic acids research
Trost H,Merkell A,Lopezcolorado FW,Stark JM
Wed Jan 25 00:00:00 UTC 2023
RIF1 suppresses the formation of single-stranded ultrafine anaphase bridges via protein phosphatase 1.
Cell reports
Kong N,Liu Z,Chan YW
Tue Feb 28 00:00:00 UTC 2023
Centromeres as universal hotspots of DNA breakage, driving RAD51-mediated recombination during quiescence.
Molecular cell
Saayman X,Graham E,Nathan WJ,Nussenzweig A,Esashi F
Thu Feb 16 00:00:00 UTC 2023
TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT.
EMBO molecular medicine
de Nonneville A,Salas S,Bertucci F,Sobinoff AP,Adélaïde J,Guille A,Finetti P,Noble JR,Churikov D,Chaffanet M,Lavit E,Pickett HA,Bouvier C,Birnbaum D,Reddel RR,Géli V
Mon Oct 10 00:00:00 UTC 2022
The human mitochondrial genome contains a second light strand promoter.
Molecular cell
Tan BG,Mutti CD,Shi Y,Xie X,Zhu X,Silva-Pinheiro P,Menger KE,Díaz-Maldonado H,Wei W,Nicholls TJ,Chinnery PF,Minczuk M,Falkenberg M,Gustafsson CM
Thu Oct 06 00:00:00 UTC 2022
Top3α is the replicative topoisomerase in mitochondrial DNA replication.
Nucleic acids research
Hangas A,Kekäläinen NJ,Potter A,Michell C,Aho KJ,Rutanen C,Spelbrink JN,Pohjoismäki JL,Goffart S
Fri Aug 26 00:00:00 UTC 2022
Top3α is the replicative topoisomerase in mitochondrial DNA replication.
Nucleic acids research
Hangas A,Kekäläinen NJ,Potter A,Michell C,Aho KJ,Rutanen C,Spelbrink JN,Pohjoismäki JL,Goffart S
Fri Aug 26 00:00:00 UTC 2022
The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication.
Science advances
Jiang M,Xie X,Zhu X,Jiang S,Milenkovic D,Misic J,Shi Y,Tandukar N,Li X,Atanassov I,Jenninger L,Hoberg E,Albarran-Gutierrez S,Szilagyi Z,Macao B,Siira SJ,Carelli V,Griffith JD,Gustafsson CM,Nicholls TJ,Filipovska A,Larsson NG,Falkenberg M
Thu Jul 01 00:00:00 UTC 2021
The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.
Nature communications
Shorrocks AK,Jones SE,Tsukada K,Morrow CA,Belblidia Z,Shen J,Vendrell I,Fischer R,Kessler BM,Blackford AN
Tue Jan 26 00:00:00 UTC 2021
PrimPol-mediated repriming facilitates replication traverse of DNA interstrand crosslinks.
The EMBO journal
González-Acosta D,Blanco-Romero E,Ubieto-Capella P,Mutreja K,Míguez S,Llanos S,García F,Muñoz J,Blanco L,Lopes M,Méndez J
Thu Jul 15 00:00:00 UTC 2021
Nuclear envelope tethering inhibits the formation of ALT-associated PML bodies in ALT cells.
Aging
Yang CW,Hsieh MH,Sun HJ,Teng SC
Sun Apr 04 00:00:00 UTC 2021
Predominant cellular mitochondrial dysfunction in the TOP3A gene-caused Bloom syndrome-like disorder.
Biochimica et biophysica acta. Molecular basis of disease
Jiang W,Jia N,Guo C,Wen J,Wu L,Ogi T,Zhang H
Tue Jun 01 00:00:00 UTC 2021
FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops.
Scientific reports
Pan X,Chen Y,Biju B,Ahmed N,Kong J,Goldenberg M,Huang J,Mohan N,Klosek S,Parsa K,Guh CY,Lu R,Pickett HA,Chu HP,Zhang D
Fri Dec 13 00:00:00 UTC 2019
Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA.
Molecular cell
Nicholls TJ,Nadalutti CA,Motori E,Sommerville EW,Gorman GS,Basu S,Hoberg E,Turnbull DM,Chinnery PF,Larsson NG,Larsson E,Falkenberg M,Taylor RW,Griffith JD,Gustafsson CM
Thu Jan 04 00:00:00 UTC 2018
Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA.
Molecular cell
Nicholls TJ,Nadalutti CA,Motori E,Sommerville EW,Gorman GS,Basu S,Hoberg E,Turnbull DM,Chinnery PF,Larsson NG,Larsson E,Falkenberg M,Taylor RW,Griffith JD,Gustafsson CM
Thu Jan 04 00:00:00 UTC 2018
Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2.
Nucleic acids research
Hangas A,Aasumets K,Kekäläinen NJ,Paloheinä M,Pohjoismäki JL,Gerhold JM,Goffart S
Fri Oct 12 00:00:00 UTC 2018
Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2.
Nucleic acids research
Hangas A,Aasumets K,Kekäläinen NJ,Paloheinä M,Pohjoismäki JL,Gerhold JM,Goffart S
Fri Oct 12 00:00:00 UTC 2018
Mutations in TOP3A Cause a Bloom Syndrome-like Disorder.
American journal of human genetics
Martin CA,Sarlós K,Logan CV,Thakur RS,Parry DA,Bizard AH,Leitch A,Cleal L,Ali NS,Al-Owain MA,Allen W,Altmüller J,Aza-Carmona M,Barakat BAY,Barraza-García J,Begtrup A,Bogliolo M,Cho MT,Cruz-Rojo J,Dhahrabi HAM,Elcioglu NH,Gorman GS,Jobling R,Kesterton I,Kishita Y,Kohda M,Le Quesne Stabej P,Malallah AJ,Nürnberg P,Ohtake A,Okazaki Y,Pujol R,Ramirez MJ,Revah-Politi A,Shimura M,Stevens P,Taylor RW,Turner L,Williams H,Wilson C,Yigit G,Zahavich L,Alkuraya FS,Surralles J,Iglesias A,Murayama K,Wollnik B,Dattani M,Heath KE,Hickson ID,Jackson AP
Thu Aug 02 00:00:00 UTC 2018
Mutations in TOP3A Cause a Bloom Syndrome-like Disorder.
American journal of human genetics
Martin CA,Sarlós K,Logan CV,Thakur RS,Parry DA,Bizard AH,Leitch A,Cleal L,Ali NS,Al-Owain MA,Allen W,Altmüller J,Aza-Carmona M,Barakat BAY,Barraza-García J,Begtrup A,Bogliolo M,Cho MT,Cruz-Rojo J,Dhahrabi HAM,Elcioglu NH,Gorman GS,Jobling R,Kesterton I,Kishita Y,Kohda M,Le Quesne Stabej P,Malallah AJ,Nürnberg P,Ohtake A,Okazaki Y,Pujol R,Ramirez MJ,Revah-Politi A,Shimura M,Stevens P,Taylor RW,Turner L,Williams H,Wilson C,Yigit G,Zahavich L,Alkuraya FS,Surralles J,Iglesias A,Murayama K,Wollnik B,Dattani M,Heath KE,Hickson ID,Jackson AP
Thu Aug 02 00:00:00 UTC 2018
Mutations in TOP3A Cause a Bloom Syndrome-like Disorder.
American journal of human genetics
Martin CA,Sarlós K,Logan CV,Thakur RS,Parry DA,Bizard AH,Leitch A,Cleal L,Ali NS,Al-Owain MA,Allen W,Altmüller J,Aza-Carmona M,Barakat BAY,Barraza-García J,Begtrup A,Bogliolo M,Cho MT,Cruz-Rojo J,Dhahrabi HAM,Elcioglu NH,Gorman GS,Jobling R,Kesterton I,Kishita Y,Kohda M,Le Quesne Stabej P,Malallah AJ,Nürnberg P,Ohtake A,Okazaki Y,Pujol R,Ramirez MJ,Revah-Politi A,Shimura M,Stevens P,Taylor RW,Turner L,Williams H,Wilson C,Yigit G,Zahavich L,Alkuraya FS,Surralles J,Iglesias A,Murayama K,Wollnik B,Dattani M,Heath KE,Hickson ID,Jackson AP
Thu Sep 06 00:00:00 UTC 2018
Mutations in TOP3A Cause a Bloom Syndrome-like Disorder.
American journal of human genetics
Martin CA,Sarlós K,Logan CV,Thakur RS,Parry DA,Bizard AH,Leitch A,Cleal L,Ali NS,Al-Owain MA,Allen W,Altmüller J,Aza-Carmona M,Barakat BAY,Barraza-García J,Begtrup A,Bogliolo M,Cho MT,Cruz-Rojo J,Dhahrabi HAM,Elcioglu NH,Gorman GS,Jobling R,Kesterton I,Kishita Y,Kohda M,Le Quesne Stabej P,Malallah AJ,Nürnberg P,Ohtake A,Okazaki Y,Pujol R,Ramirez MJ,Revah-Politi A,Shimura M,Stevens P,Taylor RW,Turner L,Williams H,Wilson C,Yigit G,Zahavich L,Alkuraya FS,Surralles J,Iglesias A,Murayama K,Wollnik B,Dattani M,Heath KE,Hickson ID,Jackson AP
Thu Sep 06 00:00:00 UTC 2018
HERC2 Facilitates BLM and WRN Helicase Complex Interaction with RPA to Suppress G-Quadruplex DNA.
Cancer research
Wu W,Rokutanda N,Takeuchi J,Lai Y,Maruyama R,Togashi Y,Nishikawa H,Arai N,Miyoshi Y,Suzuki N,Saeki Y,Tanaka K,Ohta T
Thu Nov 15 00:00:00 UTC 2018
BLM helicase regulates DNA repair by counteracting RAD51 loading at DNA double-strand break sites.
The Journal of cell biology
Patel DS,Misenko SM,Her J,Bunting SF
Mon Nov 06 00:00:00 UTC 2017
BLM helicase regulates DNA repair by counteracting RAD51 loading at DNA double-strand break sites.
The Journal of cell biology
Patel DS,Misenko SM,Her J,Bunting SF
Mon Nov 06 00:00:00 UTC 2017
RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability.
The Journal of cell biology
Chang EY,Novoa CA,Aristizabal MJ,Coulombe Y,Segovia R,Chaturvedi R,Shen Y,Keong C,Tam AS,Jones SJM,Masson JY,Kobor MS,Stirling PC
Mon Dec 04 00:00:00 UTC 2017
TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.
Molecular cell
Blackford AN,Nieminuszczy J,Schwab RA,Galanty Y,Jackson SP,Niedzwiedz W
Thu Mar 19 00:00:00 UTC 2015
TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.
Molecular cell
Blackford AN,Nieminuszczy J,Schwab RA,Galanty Y,Jackson SP,Niedzwiedz W
Thu Mar 19 00:00:00 UTC 2015
FANCD2, FANCJ and BRCA2 cooperate to promote replication fork recovery independently of the Fanconi Anemia core complex.
Cell cycle (Georgetown, Tex.)
Raghunandan M,Chaudhury I,Kelich SL,Hanenberg H,Sobeck A
Wed Dec 02 00:00:00 UTC 2015
FANCD2-controlled chromatin access of the Fanconi-associated nuclease FAN1 is crucial for the recovery of stalled replication forks.
Molecular and cellular biology
Chaudhury I,Stroik DR,Sobeck A
Sat Nov 01 00:00:00 UTC 2014
FANCD2-controlled chromatin access of the Fanconi-associated nuclease FAN1 is crucial for the recovery of stalled replication forks.
Molecular and cellular biology
Chaudhury I,Stroik DR,Sobeck A
Sat Nov 01 00:00:00 UTC 2014
FANCD2 regulates BLM complex functions independently of FANCI to promote replication fork recovery.
Nucleic acids research
Chaudhury I,Sareen A,Raghunandan M,Sobeck A
Mon Jul 01 00:00:00 UTC 2013
FANCD2 regulates BLM complex functions independently of FANCI to promote replication fork recovery.
Nucleic acids research
Chaudhury I,Sareen A,Raghunandan M,Sobeck A
Mon Jul 01 00:00:00 UTC 2013
