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Product Details
PA5-72961
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A genomic peptide made to a C-terminal region of the human TP53INP2 protein (within residues 100-220). [Swiss-Prot Q8IXH6]
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 30% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2718815
Target Information
TP53INP2 (tumor protein p53 inducible nuclear protein 2), also known as DOR or PINH, is a 220 amino acid nuclear protein that is expressed in developing murine brain and spinal cord, as well as in the sensory and motor neuron tracts of the peripheral nervous system. A novel protein involved in the autophagy of mammalian cells, TP53INP2 translocates from the nucleus to the autophagosome structures after activation of autophagy by rapamycin or starvation. Necessary for autophagosome development and considered a scaffold protein, TP53INP2 recruits LC3 and/or LC3-related proteins, such as GABARAP and GABARAP-like2, to the autophagosome membrane by interacting with the transmembrane protein TMEM49. The gene encoding TP53INP2 is located on human chromosome 20, which is comprised of approximately 2% of the human genome and contains nearly 63 million bases that encode over 600 genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: diabetes and obesity regulated; diabetes and obesity-regulated; Diabetes and obesity-regulated gene; Diabetes and obesity-regulated protein; p53-inducible protein U; PIG-U; tumor protein p53 inducible nuclear protein 2; Tumor protein p53-inducible nuclear protein 2
Gene Aliases: 1110029F20Rik; C20orf110; dJ1181N3.1; DOR; PIG-U; PINH; TP53INP2; Trp53inp2
UniProt ID: (Human) Q8IXH6, (Mouse) Q8CFU8
Entrez Gene ID: (Human) 58476, (Mouse) 68728
autophagosome assembly
osteoblast differentiation
tissue homeostasis
transcription, DNA-templated
ubiquitin-dependent protein catabolic process
positive regulation of autophagy
positive regulation of transcription, DNA-templated
negative regulation of cellular protein localization
regulation of transcription, DNA-templated
autophagy
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