Invitrogen

TP63 Recombinant Rabbit Monoclonal Antibody (10H7L17)

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2 Published Figures
2 References

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

703809

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
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Immunocytochemistry (ICC/IF)

1:100
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Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

10H7L17

Immunogen

Protein corresponding to human TP63 [aa360-aa500]
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2809251

Product Specific Information

This antibody is predicted to react with Monkey, Mouse, Rat, Bovine.

Target Information

TP63 (tumor protein 63) acts as a sequence-specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform-specific activity. Isoform 2 activates RIPK4 transcription. TP63 may be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. It is involved in Notch signaling by inducing JAG1 and JAG2. TP63 plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. TP63 is required for limb formation from the apical ectodermal ridge. It also activates transcription of the p21 promoter. Mutations affecting the gene can result in Acro-dermato-ungual-lacrimal-tooth syndrome, ankyloblepharon-ectodermal defects-cleft lip/palate, ectrodactyly ectodermal dysplasia, split-hand/foot malformation 4, limb-mammary syndrome, ectodermal dysplasia - Rapp-Hodgkin type, and orofacial cleft 8.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: amplified in squamous cell carcinoma; Chronic ulcerative stomatitis protein; CUSP; Keratinocyte transcription factor KET; p40; p51; p63; p63a; p73L; TP63; Transformation-related protein 63; Tumor protein 63; tumor protein p53-competing protein; Tumor protein p73-like

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Gene Aliases: AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; p40; p51; p53CP; P63; P73H; P73L; RHS; SHFM4; TP53CP; TP53L; TP63; TP73L

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UniProt ID: (Human) Q9H3D4

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Entrez Gene ID: (Human) 8626

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Function(s)
transcription factor activity, transcription factor binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding p53 binding DNA binding chromatin binding damaged DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding identical protein binding sequence-specific DNA binding transcription regulatory region DNA binding metal ion binding WW domain binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter replicative cell aging skeletal system development establishment of planar polarity positive regulation of mesenchymal cell proliferation epithelial cell development chromatin remodeling transcription from RNA polymerase II promoter apoptotic process DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Notch signaling pathway spermatogenesis ectoderm and mesoderm interaction proximal/distal pattern formation response to X-ray multicellular organism aging response to gamma radiation epidermal cell division regulation of epidermal cell division positive regulation of keratinocyte proliferation keratinocyte differentiation embryonic limb morphogenesis polarized epithelial cell differentiation hair follicle morphogenesis mitotic G1 DNA damage checkpoint cellular response to UV post-anal tail morphogenesis odontogenesis of dentin-containing tooth intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of apoptotic process negative regulation of apoptotic process regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of neuron apoptotic process skin morphogenesis keratinocyte proliferation negative regulation of keratinocyte differentiation positive regulation of osteoblast differentiation positive regulation of Notch signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter sympathetic nervous system development smooth muscle tissue development female genitalia morphogenesis protein homotetramerization neuron apoptotic process urinary bladder development cloacal septation prostatic bud formation squamous basal epithelial stem cell differentiation involved in prostate gland acinus development establishment of skin barrier positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway regulation of signal transduction by p53 class mediator positive regulation of fibroblast apoptotic process negative regulation of mesoderm development
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