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TPCN1 Antibody (ACC-071-200UL) in IHC (P)
Expression of Two pore calcium channel protein 1 in rat lung - Immunohistochemical staining of paraffin embedded rat lung sections using Anti-TPCN1 Antibody (#ACC-071), (1:100). TPCN1 is expressed in the respiratory epithelium of thebronchiole (black arrows), in the smooth muscle of bothbronchiole (red arrows) and blood vessels (blue arrows). Hematoxilin is used as the counterstain.
Product Details
ACC-071-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)RNLRQIFQSLPPFMD, corresponding to amino acid residues 221-235 of rat TPCN1, 2ndluminal loop
Conjugate
Form
Lyophilized
Concentration
0.9 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
Target Information
TPCN1 may function as one of the major voltage-gated Ca2+ channel (VDCC) across the plasma membrane. Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ20612; Two pore calcium channel protein 1; two pore channel 1; Two pore channel protein 1; two-pore channel 1; two-pore channel 1, homolog; two-pore segment channel 1; Voltage-dependent calcium channel protein TPC1; voltage-gated Ca channel
Gene Aliases: 5730403B01Rik; KIAA1169; mKIAA1169; TPC1; TPCN1
UniProt ID: (Human) Q9ULQ1, (Mouse) Q9EQJ0, (Rat) Q9WTN5
Entrez Gene ID: (Human) 53373, (Mouse) 252972, (Rat) 246215
transport
ion transport
calcium ion transport
ion transmembrane transport
regulation of ion transmembrane transport
transmembrane transport
calcium ion transmembrane transport
membrane depolarization during action potential
positive regulation of autophagy
release of sequestered calcium ion into cytosol
biological_process
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