Bethyl Laboratories

TPR Polyclonal Antibody

View all (14) TPR antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

IHC-00099

Applications
Tested Dilution
Publications

Immunohistochemistry (IHC)

1:100-1:500
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Region between residue 2300 and the C-terminus (residue 2349) of Human Translocated Promoter Region Protein.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

TBS, pH 7.0 to 8.0, with 0.1% BSA

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Based on 100% sequence identity, this antibody is predicted to react with Bovine, Dog, Rabbit, Pig, Panda, Monkey, Gorilla, Chimpanzee, Northern white-cheeked gibbon and Little brown bat

Target Information

Steroidogenic factor-1 (SF-1) regulates multiple genes involved in the adrenal and gonadal development and in the biosynthesis of a variety of hormones, including adrenal and gonadal steroids, anti-Mullerian hormone (AMH), and gonadotropins. SF-1 belongs to the fushi tarazu factor-1 (FTZ-F1) subfamily of orphan nuclear receptors. In the adult ovary, SF-1 localizes to theca/interstitial cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Megator; NPC-associated intranuclear protein; nuclear pore complex-associated protein TPR; Nucleoprotein TPR; translocated promoter region (to activated MET oncogene); Translocated promoter region and nuclear basket protein; Translocated promoter region protein; tumor potentiating region

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Gene Aliases: 2610029M07Rik; C77892; TPR

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UniProt ID: (Human) P12270, (Mouse) F6ZDS4

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Entrez Gene ID: (Human) 7175, (Mouse) 108989

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Function(s)
molecular_function chromatin binding mRNA binding transporter activity nucleocytoplasmic transporter activity protein binding tubulin binding heat shock protein binding protein homodimerization activity protein anchor poly(A) RNA binding mitogen-activated protein kinase binding dynein complex binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter MAPK import into nucleus RNA import into nucleus RNA export from nucleus protein import into nucleus transport cell cycle mitotic nuclear division mitotic spindle assembly checkpoint regulation of mitotic sister chromatid separation protein transport positive regulation of heterochromatin assembly mRNA export from nucleus in response to heat stress cellular response to heat cellular response to interferon-alpha positive regulation of protein import into nucleus negative regulation of translational initiation positive regulation of protein export from nucleus negative regulation of RNA export from nucleus mRNA transport cell division response to epidermal growth factor positive regulation of mitotic cell cycle spindle assembly checkpoint positive regulation of intracellular protein transport regulation of mitotic spindle assembly mRNA export from nucleus tRNA export from nucleus protein export from nucleus nuclear pore organization mitotic nuclear envelope disassembly biological_process regulation of mRNA export from nucleus regulation of glucose transport viral process protein sumoylation viral transcription gene silencing by RNA regulation of protein stability regulation of protein import into nucleus nuclear matrix organization regulation of protein export from nucleus nuclear pore complex assembly intracellular transport of virus regulation of cellular response to heat
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