Invitrogen

TPR Polyclonal Antibody

View all (14) TPR antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-40126

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human TPR. The exact sequence is proprietary.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.37 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2609474

Product Specific Information

Recommended positive controls: mouse lung tissue.

Predicted reactivity: Mouse (100%), Rat (100%), Bovine (100%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Steroidogenic factor-1 (SF-1) regulates multiple genes involved in the adrenal and gonadal development and in the biosynthesis of a variety of hormones, including adrenal and gonadal steroids, anti-Mullerian hormone (AMH), and gonadotropins. SF-1 belongs to the fushi tarazu factor-1 (FTZ-F1) subfamily of orphan nuclear receptors. In the adult ovary, SF-1 localizes to theca/interstitial cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Megator; NPC-associated intranuclear protein; nuclear pore complex-associated protein TPR; Nucleoprotein TPR; translocated promoter region (to activated MET oncogene); Translocated promoter region and nuclear basket protein; Translocated promoter region protein; tumor potentiating region

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Gene Aliases: 2610029M07Rik; C77892; TPR

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UniProt ID: (Human) P12270, (Mouse) F6ZDS4

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Entrez Gene ID: (Human) 7175, (Mouse) 108989

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Function(s)
molecular_function chromatin binding mRNA binding transporter activity nucleocytoplasmic transporter activity protein binding tubulin binding heat shock protein binding protein homodimerization activity protein anchor poly(A) RNA binding mitogen-activated protein kinase binding dynein complex binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter MAPK import into nucleus RNA import into nucleus RNA export from nucleus protein import into nucleus transport cell cycle mitotic nuclear division mitotic spindle assembly checkpoint regulation of mitotic sister chromatid separation protein transport positive regulation of heterochromatin assembly mRNA export from nucleus in response to heat stress cellular response to heat cellular response to interferon-alpha positive regulation of protein import into nucleus negative regulation of translational initiation positive regulation of protein export from nucleus negative regulation of RNA export from nucleus mRNA transport cell division response to epidermal growth factor positive regulation of mitotic cell cycle spindle assembly checkpoint positive regulation of intracellular protein transport regulation of mitotic spindle assembly mRNA export from nucleus tRNA export from nucleus protein export from nucleus nuclear pore organization mitotic nuclear envelope disassembly biological_process regulation of mRNA export from nucleus regulation of glucose transport viral process protein sumoylation viral transcription gene silencing by RNA regulation of protein stability regulation of protein import into nucleus nuclear matrix organization regulation of protein export from nucleus nuclear pore complex assembly intracellular transport of virus regulation of cellular response to heat
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