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Product Details
H00007178-M06
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
2A3
Immunogen
TPT1 (AAH22436, 35 a.a. approximately 138 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: GVDIVMNHHL QETSFTKEAY KKYIKDYMKS IKGKLEEQRP ERVKPFMTGA AEQIKHILAN FKNYQFFIGE NMNPDGMVAL LDYREDGVTP YMIFFKDGLE MEKC
Target Information
TPT1 (translationally controlled tumor protein 1) is a 23 kDa member of the TCTP family of calcium binding proteins. TPT1 is localized in the cytoplasm and widely expressed and serves as a transcriptional activator, calcium transporter, histamine inducer and antiapoptotic caspase 3 inhibitor. TPT1 is a cytokine-like molecule that causes the release of histamine, IL-4 and IL-13 from basophils as well as the secretion of IL-8 and a calcium response in eosinophils. TPT1 plays a pivotal role in allergic diseases and due to its wide distribution in brain, is thought to be involved in neurodegenerative disorders, such as Alzheimer's disease and Down syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 21 kDa polypeptide; 21 kDa polypeptide under translational control; Fortilin; Histamine-releasing factor; HRF; Lens epithelial protein; p21; p23; TCTP; translationally regulated transcript (21 kDa); Translationally-controlled tumor protein
Gene Aliases: HRF; p02; p21; p23; TCTP; TPT1; Trt
UniProt ID: (Human) P13693, (Mouse) P63028, (Rat) P63029
Entrez Gene ID: (Human) 7178, (Mouse) 22070, (Rat) 116646
stem cell population maintenance
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of ectoderm development
spermatogenesis
cell proliferation
response to virus
calcium ion transport
cellular calcium ion homeostasis
cell differentiation
regulation of apoptotic process
negative regulation of apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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