Proteintech

TPX2 Polyclonal Antibody

TPX2 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 11

TPX2 Antibody (11741-1-AP) in ICC/IF

Immunofluorescent analysis of ( 4% PFA) fixed HeLa cells using 11741-1-AP (TPX2 antibody) at dilution of 1:100 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

TPX2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

TPX2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11741-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 11 publications 11 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TPX2 Fusion Protein Ag2334 (1-395 aa encoded by BC020207)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSQVKSSYS YDAPSDFINF SSLDDEGDTQ NIDSWFEEKA NLENKLLGKN GTGGLFQGKT PLRKANLQQA IVTPLKPVDN TYYKEAEKEN LVEQSIPSNA CSSLEVEAAI SRKTPAQPQR RSLRLSAQKD LEQKEKHHVK MKAKRCATPV IIDEILPSKK MKVSNNKKKP EEEGSAHQDT AEKNASSPEK AKGRHTVPCM PPAKQKFLKS TEEQELEKSM KMQQEVVEMR KKNEEFKKLA LAGIGQPVKK SVSQVTKSVD FHFRTDERIK QHPKNQEEYK EVNFTSELRK HPSSPARVTK GCTIVKPFNL SQGKKRTFDE TVSTYVPLAQ QVEDFHKRTP NRYHLRSKKD DINLLPSKSS VTKICRDPQT PVLQTKHRAR AVTCKSTAEL EAEELE (1-395 aa encoded by B C020207)

Target Information

The protein encoded by this gene is found in the nucleolus and is similar to that of a family of genes on the Y-chromosome. This gene is intronless. Defects in this gene are a cause of sudden infant death with dysgenesis of the testes syndrome (SIDDT).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Mcrs1 regulates G2/M transition and spindle assembly during mouse oocyte meiosis.

EMBO reports

Ju JQ,Pan ZN,Zhang KH,Ji YM,Liu JC,Sun SC

Thu May 04 00:00:00 UTC 2023

Mcrs1 regulates G2/M transition and spindle assembly during mouse oocyte meiosis.

EMBO reports

Ju JQ,Pan ZN,Zhang KH,Ji YM,Liu JC,Sun SC

Thu May 04 00:00:00 UTC 2023

Transmission of Exosomal TPX2 Promotes Metastasis and Resistance of NSCLC Cells to Docetaxel.

OncoTargets and therapy

Hu J,He Q,Tian T,Chang N,Qian L

Tue Apr 04 00:00:00 UTC 2023

miR-29c Suppresses the Malignant Phenotype of Hepatocellular Carcinoma Cells In Vitro by Mediating TPX2 Associated with Immune Infiltration.

Digestive diseases and sciences

Wang H,Chen W,Qi Y,Liu D,Liu Z,Zhang Q,Yi Y,Wang J,Wu W

Mon May 01 00:00:00 UTC 2023

miR-29c Suppresses the Malignant Phenotype of Hepatocellular Carcinoma Cells In Vitro by Mediating TPX2 Associated with Immune Infiltration.

Digestive diseases and sciences

Wang H,Chen W,Qi Y,Liu D,Liu Z,Zhang Q,Yi Y,Wang J,Wu W

Mon May 01 00:00:00 UTC 2023

Augmin-dependent microtubule self-organization drives kinetochore fiber maturation in mammals.

Cell reports

Almeida AC,Soares-de-Oliveira J,Drpic D,Cheeseman LP,Damas J,Lewin HA,Larkin DM,Aguiar P,Pereira AJ,Maiato H

Tue Apr 05 00:00:00 UTC 2022

WDR62 regulates spindle dynamics as an adaptor protein between TPX2/Aurora A and katanin.

The Journal of cell biology

Huang J,Liang Z,Guan C,Hua S,Jiang K

Mon Aug 02 00:00:00 UTC 2021

WDR62 regulates spindle dynamics as an adaptor protein between TPX2/Aurora A and katanin.

The Journal of cell biology

Huang J,Liang Z,Guan C,Hua S,Jiang K

Mon Aug 02 00:00:00 UTC 2021

Importin α phosphorylation promotes TPX2 activation by GM130 to control astral microtubules and spindle orientation.

Journal of cell science

Guo H,Wei JH,Zhang Y,Seemann J

Fri Feb 19 00:00:00 UTC 2021

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

Scientific reports

Wang H,Feng K,Wang Q,Deng H

Fri Jul 09 00:00:00 UTC 2021

Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics.

bioRxiv : the preprint server for biology

Wang L,Muneer A,Xie L,Zhang F,Wu B,Mei L,Lenarcic EM,Feng EH,Song J,Xiong Y,Yu X,Wang C,Gheorghe C,Torralba K,Cook JG,Wan YY,Moorman NJ,Song H,Jin J,Chen X

Mon Nov 16 00:00:00 UTC 2020

CCDC74A/B are K-fiber crosslinkers required for chromosomal alignment.

BMC biology

Zhou H,Zheng T,Wang T,Li Q,Wang F,Liang X,Chen J,Teng J

Sat Sep 14 00:00:00 UTC 2019

CCDC74A/B are K-fiber crosslinkers required for chromosomal alignment.

BMC biology

Zhou H,Zheng T,Wang T,Li Q,Wang F,Liang X,Chen J,Teng J

Sat Sep 14 00:00:00 UTC 2019

Dysfunction of Sister Chromatids Separation Promotes Progression of Hepatocellular Carcinoma According to Analysis of Gene Expression Profiling.

Frontiers in physiology

Sun B,Lin G,Ji D,Li S,Chi G,Jin X

Wed Mar 30 00:00:00 UTC 2022

Dysfunction of Sister Chromatids Separation Promotes Progression of Hepatocellular Carcinoma According to Analysis of Gene Expression Profiling.

Frontiers in physiology

Sun B,Lin G,Ji D,Li S,Chi G,Jin X

Wed Mar 30 00:00:00 UTC 2022

Targeting protein for Xenopus kinesin-like protein 2 knockdown enhances radiation sensitivity of human lung squamous carcinoma cell.

Clinical and experimental pharmacology & physiology

Yang J,Gao F,Xu X,Wang Y,Zhu S

Sun Oct 01 00:00:00 UTC 2017

Targeting protein for Xenopus kinesin-like protein 2 knockdown enhances radiation sensitivity of human lung squamous carcinoma cell.

Clinical and experimental pharmacology & physiology

Yang J,Gao F,Xu X,Wang Y,Zhu S

Sun Oct 01 00:00:00 UTC 2017

Targeting protein for Xenopus kinesin-like protein 2 knockdown enhances radiation sensitivity of human lung squamous carcinoma cell.

Clinical and experimental pharmacology & physiology

Yang J,Gao F,Xu X,Wang Y,Zhu S

Sun Oct 01 00:00:00 UTC 2017

Targeting protein for Xenopus kinesin-like protein 2 knockdown enhances radiation sensitivity of human lung squamous carcinoma cell.

Clinical and experimental pharmacology & physiology

Yang J,Gao F,Xu X,Wang Y,Zhu S

Sun Oct 01 00:00:00 UTC 2017

Expression of microtubule-associated protein TPX2 in human gastric carcinoma and its prognostic significance.

Cancer cell international

Shao C,Duan C,Wang J,Luan S,Gao Y,Jin D,Wang D,Li Y,Xu L

Wed Sep 30 00:00:00 UTC 2020

Expression of microtubule-associated protein TPX2 in human gastric carcinoma and its prognostic significance.

Cancer cell international

Shao C,Duan C,Wang J,Luan S,Gao Y,Jin D,Wang D,Li Y,Xu L

Wed Sep 30 00:00:00 UTC 2020

Expression of microtubule-associated protein TPX2 in human gastric carcinoma and its prognostic significance.

Cancer cell international

Shao C,Duan C,Wang J,Luan S,Gao Y,Jin D,Wang D,Li Y,Xu L

Wed Sep 30 00:00:00 UTC 2020

Expression of microtubule-associated protein TPX2 in human gastric carcinoma and its prognostic significance.

Cancer cell international

Shao C,Duan C,Wang J,Luan S,Gao Y,Jin D,Wang D,Li Y,Xu L

Wed Sep 30 00:00:00 UTC 2020

Loss of protein phosphatase 6 in oocytes causes failure of meiosis II exit and impaired female fertility.

Journal of cell science

Hu MW,Wang ZB,Teng Y,Jiang ZZ,Ma XS,Hou N,Cheng X,Schatten H,Xu X,Yang X,Sun QY

Thu Oct 15 00:00:00 UTC 2015

Loss of protein phosphatase 6 in oocytes causes failure of meiosis II exit and impaired female fertility.

Journal of cell science

Hu MW,Wang ZB,Teng Y,Jiang ZZ,Ma XS,Hou N,Cheng X,Schatten H,Xu X,Yang X,Sun QY

Thu Oct 15 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: Differentially expressed in cancerous and non-cancerous lung cells 2; differentially expressed in lung cells; DIL-2; GD: HCA519; Hepatocellular carcinoma-associated antigen 519; Hepatocellular carcinoma-associated antigen 90; p100; preferentially expressed in colorectal cancer; Protein fls353; restricted expression proliferation associated protein 100; Restricted expression proliferation-associated protein 100; Targeting protein for Xklp2; TPX 2; TPX2, microtubule-associated protein homolog; TPX2, microtubule-associated, homolog

View more View less

Gene Aliases: 2610005B21Rik; C20orf1; C20orf2; DIL-2; DIL2; FLS353; GD:C20orf1; HCA519; HCTP4; p100; REPP86; TPX2

View more View less

UniProt ID: (Human) Q9ULW0, (Mouse) A2APB8

View more View less

Entrez Gene ID: (Human) 22974, (Rat) 311546, (Mouse) 72119

View more View less

Function(s)

protein binding ATP binding GTP binding protein kinase binding importin-alpha family protein binding

Process(es)

mitotic nuclear division activation of protein kinase activity regulation of mitotic spindle organization apoptotic process cell cycle spindle assembly cell division G2/M transition of mitotic cell cycle cell proliferation mitotic spindle assembly regulation of signal transduction by p53 class mediator

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

TPX2 Polyclonal Antibody

TPX2 Antibody (11741-1-AP) in ICC/IF

Product Details

11741-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!