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TR2 Antibody (PA5-115668) in IHC (P)
Immunohistochemistry analysis of TR2 in human kidney tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115668) at a dilution of 1:100. Secondary staining was applied with HRP conjugated goat anti-rabbit.
Product Details
PA5-115668
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human NR2C1(Accession P13056), corresponding to amino acid residues G78-V128.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2900303
Product Specific Information
Antibody detects endogenous levels of total NR2C1.
Target Information
This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 80-3 cNDA; early embryonic nuclear receptor; mTR2; nr2c1; Nuclear receptor subfamily 2 group C member 1; nuclear receptor subfamily 2, group C isoform; nuclear receptor subfamily 2, group C, member 1; nuclear receptor subfamily 2, group H, member 1; Orphan nuclear receptor TR2; orphan receptor, TR2-11; pregnancy specific beta-1-glycoprotein 4; Testicular receptor 2; TR2 nuclear hormone receptor
Gene Aliases: 4831444H07Rik; 80.3; Eenr; NR2C1; Psg4; TR2; TR2-11
UniProt ID: (Human) P13056, (Mouse) Q505F1, (Rat) Q8VIJ4
Entrez Gene ID: (Human) 7181, (Mouse) 22025, (Rat) 252924
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
steroid hormone receptor activity
receptor activity
protein binding
zinc ion binding
protein homodimerization activity
histone deacetylase binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
metal ion binding
negative regulation of transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
steroid hormone mediated signaling pathway
positive regulation of retinoic acid receptor signaling pathway
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
Performance Guarantee
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