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Invitrogen
TRABD2B Polyclonal Antibody
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FIGURE: 1 / 2
TRABD2B Antibody (PA5-144356) in ICC/IF
Immunocytochemistry analysis of HeLa cells with TRABD2B polyclonal antibody (Product # PA5-144356) at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
Product Details
PA5-144356
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Metalloprotease TIKI2 protein (195-405AA)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% Proclin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Wet ice
RRID
AB_3091502
Target Information
TRABD2B (TraB Domain Containing 2B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and Wnt-protein binding. An important paralog of this gene is TRABD2A. Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Heart, kidney and adipose-enriched transmembrane protein homolog; Metalloprotease TIKI2; TIKI2; TRAB domain-containing protein 2B; UPF0632 Protein A
Gene Aliases: HKAT; TIKI2; TRABD2B
UniProt ID: (Human) A6NFA1
Entrez Gene ID: (Human) 388630
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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