Proteintech

TRADD Polyclonal Antibody

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TRADD Antibody (15468-1-AP) in WB

Various lysates were subjected to SDS PAGE followed by western blot with (Product # 15468-1-AP) TRADD antibody at dilution of 1:1,000 incubated at room temperature for 1.5 hours.

TRADD Antibody in Immunoprecipitation (IP)

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Product Details

15468-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 4 publications 4 publications

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TRADD Fusion Protein Ag7768 (1-312 aa encoded by BC004491)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAAGQNGHE EWVGSAYLFV ESSLDKVVLS DAYAHPQQKV AVYRALQAAL AESGGSPDVL QMLKIHRSDP QLIVQLRFCG RQPCGRFLRA YREGALRAAL QRSLAAALAQ HSVPLQLELR AGAERLDALL ADEERCLSCI LAQQPDRLRD EELAELEDAL RNLKCGSGAR GGDGEVASAP LQPPVPSLSE VKPPPPPPPA QTFLFQGQPV VNRPLSLKDQ QTFARSVGLK WRKVGRSLQR GCRALRDPAL DSLAYEYERE GLYEQAFQLL RRFVQAEGRR ATLQRLVEAL EENELTSLAE DLLGLTDPNG GLA (1-312 aa encoded by BC004491)

Target Information

TRADD (Tumor necrosis factor receptor type 1-associated DEATH domain protein) is an important mediator of FAS and TNFR1 associated apoptotic signaling. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12. TRADD acts by interacting with TRIP12 and leading to the disruption of the interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A. TRADD acts as an adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interation with FADD. Overexpression of TRADD leads to two major TNF-induced responses - apoptosis and activation of NF-kappa-B.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Mannan-Binding Lectin Deficiency Limits Inflammation-induced Myeloid-Derived Suppressor Cells Expansion via Modulating Tumor Necrosis Factor Alpha-triggered Apoptosis.

International journal of biological sciences

Dong L,Jiang H,Chen K,Xie J,An Q,Deng F,Sun Z,Liu Y,Zhou J,Zhang L,Lu X,Wang M,Chen Z,Zou X,Zuo D

Fri Apr 15 00:00:00 UTC 2022

Kv7.4 channel is a key regulator of vascular inflammation and remodeling in neointimal hyperplasia and abdominal aortic aneurysms.

Free radical biology & medicine

Fan XZ,Wang YY,Cui ZY,Cheng ZH,Zhang HL,Gamper N,Zhang F,Han M

Sat Jan 01 00:00:00 UTC 2022

Kv7.4 channel is a key regulator of vascular inflammation and remodeling in neointimal hyperplasia and abdominal aortic aneurysms.

Free radical biology & medicine

Fan XZ,Wang YY,Cui ZY,Cheng ZH,Zhang HL,Gamper N,Zhang F,Han M

Sat Jan 01 00:00:00 UTC 2022

Kv7.4 channel is a key regulator of vascular inflammation and remodeling in neointimal hyperplasia and abdominal aortic aneurysms.

Free radical biology & medicine

Fan XZ,Wang YY,Cui ZY,Cheng ZH,Zhang HL,Gamper N,Zhang F,Han M

Sat Jan 01 00:00:00 UTC 2022

The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8.

Cell research

Zhang JY,Zhou B,Sun RY,Ai YL,Cheng K,Li FN,Wang BR,Liu FJ,Jiang ZH,Wang WJ,Zhou D,Chen HZ,Wu Q

Wed Sep 01 00:00:00 UTC 2021

Knockdown of circROBO2 attenuates acute myocardial infarction through regulating the miR-1184/TRADD axis.

Molecular medicine (Cambridge, Mass.)

Chen TP,Zhang NJ,Wang HJ,Hu SG,Geng X

Wed Mar 03 00:00:00 UTC 2021

Bioinformatics

Protein Aliases: Hs89862; MGC11078; TNF receptor 1 associated signal transducer; TNFR1-associated DEATH domain protein; TNFRSF1A-associated via death domain; tradd; tumor necrosis factor receptor type 1 associated death domain protein; Tumor necrosis factor receptor type 1-associated DEATH domain protein; tumor necrosis factor receptor-1-associated protein

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Gene Aliases: 9130005N23Rik; AA930854; Hs.89862; TRADD

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UniProt ID: (Human) Q15628, (Mouse) Q3U0V2

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Entrez Gene ID: (Human) 8717, (Mouse) 71609

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Function(s)

signal transducer activity tumor necrosis factor receptor binding protein binding kinase binding protein complex binding identical protein binding binding, bridging death domain binding

Process(es)

apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process signal transduction I-kappaB kinase/NF-kappaB signaling extrinsic apoptotic signaling pathway via death domain receptors regulation of tumor necrosis factor-mediated signaling pathway regulation of necrotic cell death tumor necrosis factor-mediated signaling pathway positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of NF-kappaB transcription factor activity protein heterooligomerization positive regulation of hair follicle development death-inducing signaling complex assembly extrinsic apoptotic signaling pathway activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of apoptotic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TRADD Polyclonal Antibody

TRADD Antibody (15468-1-AP) in WB

Product Details

15468-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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