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Product Details
H00010758-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TRAF3IP2 (NP_679211.1, 1 a.a. approximately 565 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MNRSIPVEVD ESEPYPSQLL KPIPEYSPEE ESEPPAPNIR NMAPNSLSAP TMLHNSSGDF SQAHSTLKLA NHQRPVSRQV TCLRTQVLED SEDSFCRRHP GLGKAFPSGC SAVSEPASES VVGALPAEHQ FSFMEKRNQW LVSQLSAASP DTGHDSDKSD QSLPNASADS LGGSQEMVQR PQPHRNRAGL DLPTIDTGYD SQPQDVLGIR QLERPLPLTS VCYPQDLPRP LRSREFPQFE PQRYPACAQM LPPNLSPHAP WNYHYHCPGS PDHQVPYGHD YPRAAYQQVI QPALPGQPLP GASVRGLHPV QKVILNYPSP WDQEERPAQR DCSFPGLPRH QDQPHHQPPN RAGAPGESLE CPAELRPQVP QPPSPAAVPR PPSNPPARGT LKTSNLPEEL RKVFITYSMD TAMEVVKFVN FLLVNGFQTA IDIFEDRIRG IDIIKWMERY LRDKTVMIIV AISPKYKQDV EGAESQLDED EHGLHTKYIH RMMQIEFIKQ GSMNFRFIPV LFPNAKKEHV PTWLQNTHVY SWPKNKKNIL LRLLREEEYV APPRGPLPTL QVVPL
Target Information
This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Two alternative transcripts encoding different proteins have been identified. A third transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ACT1; Adapter protein CIKS; Connection to IKK and SAPK/JNK; E3 ubiquitin ligase TRAF3IP2; E3 ubiquitin-protein ligase CIKS; NFkB-activating protein ACT1; Nuclear factor NF-kappa-B activator 1; RP3-487J7.3; TRAF3-interacting protein 2
Gene Aliases: ACT1; C6orf2; C6orf4; C6orf5; C6orf6; CANDF8; CIKS; PSORS13; TRAF3IP2
UniProt ID: (Human) O43734
Entrez Gene ID: (Human) 10758
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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