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TRAF5 Polyclonal Antibody

TRAF5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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TRAF5 Antibody (12868-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human prostate cancer using 12868-1-AP (TRAF5 antibody) at dilution of 1:100 (under 10x lens).

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Product Details

12868-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TRAF5 Fusion Protein Ag3519 (209-557 aa encoded by BC029600)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.28 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: DEHLAVCPE AEQDCPFKHY GCAVTDKRRN LQQHEHSALR EHMRLVLEKN VQLEEQISDL HKSLEQKESK IQQLAETIKK LEKEFKQFAQ LFGKNGSFLP NIQVFASHID KSAWLEAQVH QLLQMVNQQQ NKFDLRPLME AVDTVKQKIT LLENNDQRLA VLEEETNKHD THINIHKAQL SKNEERFKLL EGTCYNGKLI WKVTDYKMKK REAVDGHTVS IFSQSFYTSR CGYRLCARAY LNGDGSGRGS HLSLYFVVMR GEFDSLLQWP FRQRVTLMLL DQSGKKNIME TFKPDPNSSS FKRPDGEMNI ASGCPRFVAH SVLENAKNAY IKDDTLFLKV AVDLTDLEDL (209-557 aa encoded by BC029600)

Target Information

Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e. g. RANK, CD30, CD40, etc. ) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6) (1-4). TRAF5 is a 558-amino acid protein. TRAF5 is implicated in NF-kB and c-Jun NH(2)-terminal kinase/stress-activated protein kinase activation by members of the TNF receptor superfamily, including CD27, CD30, CD40, and lymphotoxin-beta receptor. Targeted disruption of TRAF5 gene causes defects in CD40-CD27 mediated lymphocyte activation (5).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Integrated analysis identifies low microRNA-215 expression as associated with a poor prognosis of patients with colorectal cancer through the IKβ-α signaling pathway.

Translational cancer research

Wang Z,Jiang X,Li Q,Jin Y,Liu X,Wang F,Mao Y,Hua D

Tue Sep 01 00:00:00 UTC 2020

Integrated analysis identifies low microRNA-215 expression as associated with a poor prognosis of patients with colorectal cancer through the IKβ-α signaling pathway.

Translational cancer research

Wang Z,Jiang X,Li Q,Jin Y,Liu X,Wang F,Mao Y,Hua D

Tue Sep 01 00:00:00 UTC 2020

Down-regulated HDAC3 elevates microRNA-495-3p to restrain epithelial-mesenchymal transition and oncogenicity of melanoma cells via reducing TRAF5.

Journal of cellular and molecular medicine

Ma Y,Duan J,Hao X

Sun Nov 01 00:00:00 UTC 2020

TRAF5 protects against myocardial ischemia reperfusion injury via AKT signaling.

European journal of pharmacology

Xu W,Zhang L,Ma S,Zhang Y,Cai Z,Zhang K,Jin D

Sun Jul 05 00:00:00 UTC 2020

TRAF5 protects against myocardial ischemia reperfusion injury via AKT signaling.

European journal of pharmacology

Xu W,Zhang L,Ma S,Zhang Y,Cai Z,Zhang K,Jin D

Sun Jul 05 00:00:00 UTC 2020

Effects of antisense lncRNA PCBP1-AS1 on biological behaviors of vulvar squamous carcinoma cells by regulating TRAF5 and NF-κB expression.

Translational cancer research

Wang H,Ouyang L,Gao S

Thu Aug 01 00:00:00 UTC 2019

Up-regulation of OLR1 expression by TBC1D3 through activation of TNFα/NF-κB pathway promotes the migration of human breast cancer cells.

Cancer letters

Wang B,Zhao H,Zhao L,Zhang Y,Wan Q,Shen Y,Bu X,Wan M,Shen C

Wed Nov 01 00:00:00 UTC 2017

Up-regulation of OLR1 expression by TBC1D3 through activation of TNFα/NF-κB pathway promotes the migration of human breast cancer cells.

Cancer letters

Wang B,Zhao H,Zhao L,Zhang Y,Wan Q,Shen Y,Bu X,Wan M,Shen C

Wed Nov 01 00:00:00 UTC 2017

DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.

Medical oncology (Northwood, London, England)

Huang W,Liu J,Feng X,Chen H,Zeng L,Huang G,Liu W,Wang L,Jia W,Chen J,Ren C

Wed Apr 01 00:00:00 UTC 2015

DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.

Medical oncology (Northwood, London, England)

Huang W,Liu J,Feng X,Chen H,Zeng L,Huang G,Liu W,Wang L,Jia W,Chen J,Ren C

Wed Apr 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: RING finger protein 84; TNF receptor-associated factor 5

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Gene Aliases: MGC:39780; RNF84; TRAF5

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UniProt ID: (Human) O00463, (Mouse) P70191

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Entrez Gene ID: (Human) 7188, (Mouse) 22033

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Function(s)

ubiquitin-protein transferase activity protein binding zinc ion binding ubiquitin protein ligase binding thioesterase binding signal transducer activity metal ion binding

Process(es)

apoptotic process signal transduction protein ubiquitination regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of cell proliferation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TRAF5 Polyclonal Antibody

TRAF5 Antibody (12868-1-AP) in IHC (P)

Product Details

12868-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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