Invitrogen

TRAF6 Polyclonal Antibody

View all (18) TRAF6 antibodies

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Datasheet
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Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-20019

Applications
Tested Dilution
Publications

Western Blot (WB)

1 µg/mL
- -

Immunocytochemistry (ICC/IF)

10 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A peptide corresponding to 14 amino acids near the C-terminus of human TRAF6.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Ion-exchange chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11155789

Product Specific Information

A suggested positive control is PC-3 cell lysate.

PA5-20019 can be used with blocking peptide PEP-0138.

Target Information

Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a NF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-kappa-B activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: E3 ubiquitin-protein ligase TRAF6; Interleukin-1 signal transducer; RING finger protein 85; RING-type E3 ubiquitin transferase TRAF6; TNF receptor-associated factor 6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase

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Gene Aliases: 2310003F17Rik; AI851288; C630032O20Rik; MGC:3310; RNF85; TRAF6

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UniProt ID: (Human) Q9Y4K3, (Rat) B5DF45, (Mouse) P70196

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Entrez Gene ID: (Human) 7189, (Rat) 311245, (Mouse) 22034

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Function(s)
ubiquitin-protein transferase activity tumor necrosis factor receptor binding protein binding zinc ion binding ligase activity protein kinase binding mitogen-activated protein kinase kinase kinase binding ubiquitin conjugating enzyme binding ubiquitin protein ligase binding thioesterase binding identical protein binding histone deacetylase binding protein kinase B binding protein N-terminus binding ubiquitin protein ligase activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter protein polyubiquitination ossification neural tube closure positive regulation of T cell cytokine production protein complex assembly immune response signal transduction I-kappaB kinase/NF-kappaB signaling activation of NF-kappaB-inducing kinase activity JNK cascade organ morphogenesis protein ubiquitination cytokine-mediated signaling pathway antigen processing and presentation of exogenous peptide antigen via MHC class II osteoclast differentiation positive regulation of lipopolysaccharide-mediated signaling pathway activation of protein kinase activity positive regulation of interleukin-2 production T-helper 1 type immune response positive regulation of T cell proliferation odontogenesis of dentin-containing tooth regulation of apoptotic process myeloid dendritic cell differentiation positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JUN kinase activity positive regulation of interleukin-12 biosynthetic process positive regulation of interleukin-6 biosynthetic process bone resorption positive regulation of osteoclast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter bone remodeling cell development positive regulation of smooth muscle cell proliferation T cell receptor signaling pathway regulation of immunoglobulin secretion positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity protein autoubiquitination interleukin-1-mediated signaling pathway protein K63-linked ubiquitination response to interleukin-1 cellular response to lipopolysaccharide positive regulation of transcription regulatory region DNA binding activation of MAPK activity stimulatory C-type lectin receptor signaling pathway toll-like receptor signaling pathway MyD88-dependent toll-like receptor signaling pathway MyD88-independent toll-like receptor signaling pathway membrane protein intracellular domain proteolysis positive regulation of protein ubiquitination toll-like receptor 9 signaling pathway Fc-epsilon receptor signaling pathway positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of T cell activation nucleotide-binding oligomerization domain containing signaling pathway
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