Proteintech

TRAF7 Polyclonal Antibody

TRAF7 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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TRAF7 Antibody (11780-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human colon cancer using 11780-1-AP (TRAF7 antibody) at dilution of 1:50 (under 10x lens).

TRAF7 Antibody in Immunoprecipitation (IP)

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Product Details

11780-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TRAF7 Fusion Protein Ag2414 (70-420 aa encoded by BC024267)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: QAALQDSMP PISTPRRSDS AISVRSLHSE SSMSLRSTFS LPEEEEEPEP LVFAEQPSVK LCCQLCCSVF KDPVITTCGH TFCRRCALKS EKCPVDNVKL TVVVNNIAVA EQIGELFIHC RHGCRVAGSG KPPIFEVDPR GCPFTIKLSA RKDHEGSCDY RPVRCPNNPS CPPLLRMNLE AHLKECEHIK CPHSKYGCTF IGNQDTYETH LETCRFEGLK EFLQQTDDRF HEMHVALAQK DQEIAFLRSM LGKLSEKIDQ LEKSLELKFD VLDENQSKLS EDLMEFRRDA SMLNDELSHI NARLNMGILG SYDPQQIFKC KGTFVGHQGP VWCLCVYSMG DLLFSGSSDK TI (70-420 aa encoded by BC024267)

Target Information

TRAFs are signal transducers for members of TNFR superfamily. These are critically involved in activation of MAP3K family members involved in NF-kappaB and JNK activation and apoptosis. TRAF7, a novel 670 A. A protein, is a human homolog of mouse Traf7 andconsists of an N-terminal RING finger domain, central TRAF domain, a coiled-coil motif and 7 WD40 repeats at the C-terminus. It has E3-ubiquitin ligase activity for self-ubiquitination. TRAF7 specifically interacts with MEKK3 and mediates MEKK3-induced AP1 and CHOP activation and induces apoptosis through Caspase-independent pathways. It is a multifunctional protein involved in sumoylation and negative regulation of c-Myb, thereby regulating proliferation and differentiation of hematopoietic cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

TRAF7 negatively regulates the RLR signaling pathway by facilitating the K48-linked ubiquitination of TBK1.

Virologica Sinica

Huang JP,Yang YX,Chen T,Wang DD,Li J,Xu LG

Thu Jun 01 00:00:00 UTC 2023

HFD-induced TRAF6 upregulation promotes liver cholesterol accumulation and fatty liver development via EZH2-mediated miR-429/PPARα axis.

Molecular therapy. Nucleic acids

Zhang Z,Wen H,Peng B,Weng J,Zeng F

Fri Jun 04 00:00:00 UTC 2021

Copy number variation analysis identifies novel CAKUT candidate genes in children with a solitary functioning kidney.

Kidney international

Westland R,Verbitsky M,Vukojevic K,Perry BJ,Fasel DA,Zwijnenburg PJ,Bökenkamp A,Gille JJ,Saraga-Babic M,Ghiggeri GM,D'Agati VD,Schreuder MF,Gharavi AG,van Wijk JA,Sanna-Cherchi S

Tue Dec 01 00:00:00 UTC 2015

Copy number variation analysis identifies novel CAKUT candidate genes in children with a solitary functioning kidney.

Kidney international

Westland R,Verbitsky M,Vukojevic K,Perry BJ,Fasel DA,Zwijnenburg PJ,Bökenkamp A,Gille JJ,Saraga-Babic M,Ghiggeri GM,D'Agati VD,Schreuder MF,Gharavi AG,van Wijk JA,Sanna-Cherchi S

Tue Dec 01 00:00:00 UTC 2015

Copy number variation analysis identifies novel CAKUT candidate genes in children with a solitary functioning kidney.

Kidney international

Westland R,Verbitsky M,Vukojevic K,Perry BJ,Fasel DA,Zwijnenburg PJ,Bökenkamp A,Gille JJ,Saraga-Babic M,Ghiggeri GM,D'Agati VD,Schreuder MF,Gharavi AG,van Wijk JA,Sanna-Cherchi S

Tue Dec 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: DKFZp586I021; E3 ubiquitin-protein ligase TRAF7; MGC7807; ring finger and WD repeat domain 1; RING finger and WD repeat-containing protein 1; RING finger protein 119; RING-type E3 ubiquitin transferase TRAF7; TNF receptor-associated factor 7; TNF receptor-associated factor 7, E3 ubiquitin protein ligase; traf7

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Gene Aliases: RFWD1; RGD1559653; RNF119; TRAF7

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UniProt ID: (Human) Q6Q0C0

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Entrez Gene ID: (Human) 84231, (Rat) 360491, (Mouse) 224619

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Function(s)

ubiquitin-protein transferase activity protein binding zinc ion binding ligase activity UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity

Process(es)

activation of MAPKKK activity transcription, DNA-templated regulation of transcription, DNA-templated apoptotic process protein ubiquitination positive regulation of MAPK cascade positive regulation of apoptotic signaling pathway negative regulation of transcription from RNA polymerase II promoter regulation of protein localization positive regulation of protein sumoylation cellular response to interleukin-6

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TRAF7 Polyclonal Antibody

TRAF7 Antibody (11780-1-AP) in IHC (P)

Product Details

11780-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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