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Invitrogen
TRANK1 Polyclonal Antibody
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FIGURE: 1 / 10
TRANK1 Antibody (PA5-144000) in ICC/IF
Immunocytochemistry analysis of TRANK1 in PC-3 cells. Enzyme antigen retrieval was performed using IHC enzyme antigen retrieval reagent for 15 mins. The cells were blocked with 10% goat serum. Samples were then incubated in TRANK1 Polyclonal antibody (Product # PA5-144000) using a dilution of 5 μg/mL. DyLight®488 Conjugated Goat Anti-Rabbit IgG was used as secondary antibody at 1:100 dilution and incubated for 30 minutes at 37°C. The section was counterstained with DAPI. Visualize using a fluorescence microscope and filter sets appropriate... View More
Product Details
PA5-144000
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived human TRANK1 recombinant protein (Position: K1926-R2763).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3075214
Product Specific Information
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Positive Control - WB: human Daudi whole cell. IHC: human liver cancer tissue, mouse brain tissue, rat brain tissue. ICC/IF: PC-3 cell. Flow: HEL cell, U251 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
The TRANK1 gene encodes the tetratricopeptide repeat and ankyrin repeat containing 1 protein, which has been associated with neurodevelopmental and psychiatric conditions, particularly bipolar disorder and schizophrenia. Located on chromosome 9, this gene contains both tetratricopeptide repeats and ankyrin repeats, which contribute to protein-protein interactions and structural stability. TRANK1 is thought to possibly participate in cellular functions related to brain development and synaptic transmission, impacting neuronal signaling and cognitive processes. Genetic studies have identified variations in the TRANK1 gene that may alter its expression, influencing susceptibility to bipolar disorder by modulating pathways related to neurotransmitter regulation and neuroplasticity. The specific mechanisms by which TRANK1 influences psychiatric disorders remain under investigation, but it is hypothesized that TRANK1's interaction with other proteins involved in signal transduction could be pivotal. Given its potential linkage to complex neurological disorders, TRANK1 serves as a significant focal point for studies aiming to understand the genetic basis of these conditions and develop targeted interventions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Lupus brain antigen 1; Lupus brain antigen 1 homolog; TPR and ankyrin repeat-containing protein 1
Gene Aliases: A230061D21Rik; C030048J01Rik; Gm187; KIAA0342; LBA1; RGD1563130; TRANK1
UniProt ID: (Human) O15050, (Mouse) Q8BV79
Entrez Gene ID: (Human) 9881, (Mouse) 320429, (Rat) 316022
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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