Proteintech

TRAPPC9 Polyclonal Antibody

TRAPPC9 Antibody in Immunocytochemistry (ICC/IF)

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TRAPPC9 Antibody (16014-1-AP) in ICC/IF

Immunofluorescent analysis of HEK-293 cells using 16014-1-AP (TRAPPC9 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

TRAPPC9 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

TRAPPC9 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

16014-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 5 publications 5 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TRAPPC9 Fusion Protein Ag8791 (563-912 aa encoded by BC006206)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SCQENLLQD LSDDGISVSG FPLSSPFRQV VRPRVEGKPV NPPESNKAGD YSHVKTLEAV LNFKYSGGPG HTEGYYRNLS LGLHVEVEPS VFFTRVSTLP ATSTRQCHLL LDVFNSTEHE LTVSTRSSEA LILHAGECQR MAIQVDKFNF ESFPESPGEK GQFANPKQLE EERREARGLE IHSKLGICWR IPSLKRSGEA SVEGLLNQLV LEHLQLAPLQ WDVLVDGQPC DREAVAACQV GDPVRLEVRL TNRSPRSVGP FALTVVPFQD HQNGVHNYDL HDTVSFVGSS TFYLDAVQPS GQSACLGALL FLYTGDFFLH IRFHEDSTSK ELPPSWFCLP SVHVCALEAQ A (563-912 aa encoded by BC006206)

Target Information

NIBP is a 1246 amino acid intracellular regulatory protein. Reports suggest that NIBP physically interacts with NIK, IKK (beta), but not IKK (alpha) or IKK (gamma) and thus acts as a novel enhancer of cytokine-induced NF-(kappa) B signaling pathway. Due to its neuronal expression NIBP is considered as a potential target for modulating the NF-(kappa) B signaling cascade in neuronal pathologies dependent upon abnormal activation of this pathway. NIBP is mainly expressed in brain, muscle, heart, and kidney.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Spatial proteomics reveals secretory pathway disturbances caused by neuropathy-associated TECPR2.

Nature communications

Nalbach K,Schifferer M,Bhattacharya D,Ho-Xuan H,Tseng WC,Williams LA,Stolz A,Lichtenthaler SF,Elazar Z,Behrends C

Thu Feb 16 00:00:00 UTC 2023

Spatial proteomics reveals secretory pathway disturbances caused by neuropathy-associated TECPR2.

Nature communications

Nalbach K,Schifferer M,Bhattacharya D,Ho-Xuan H,Tseng WC,Williams LA,Stolz A,Lichtenthaler SF,Elazar Z,Behrends C

Thu Feb 16 00:00:00 UTC 2023

RING finger 138 deregulation distorts NF-кB signaling and facilities colitis switch to aggressive malignancy.

Signal transduction and targeted therapy

Lu Y,Huang R,Ying J,Li X,Jiao T,Guo L,Zhou H,Wang H,Tuersuntuoheti A,Liu J,Chen Q,Wang Y,Su L,Guo C,Xu F,Wang Z,Lu Y,Li K,Liang J,Huang Z,Chen X,Yao J,Hu H,Cheng X,Wan Y,Chen X,Zhang N,Miao S,Cai J,Wang L,Liu C,Song W,Zhao H

Mon Jun 13 00:00:00 UTC 2022

RING finger 138 deregulation distorts NF-кB signaling and facilities colitis switch to aggressive malignancy.

Signal transduction and targeted therapy

Mon Jun 13 00:00:00 UTC 2022

A novel regulatory role of TRAPPC9 in L-plastin-mediated osteoclast actin ring formation.

Journal of cellular biochemistry

Hussein NJ,Mbimba T,Al-Adlaan AA,Ansari MY,Jaber FA,McDermott S,Kasumov T,Safadi FF

Wed Jan 01 00:00:00 UTC 2020

A novel regulatory role of TRAPPC9 in L-plastin-mediated osteoclast actin ring formation.

Journal of cellular biochemistry

Hussein NJ,Mbimba T,Al-Adlaan AA,Ansari MY,Jaber FA,McDermott S,Kasumov T,Safadi FF

Wed Jan 01 00:00:00 UTC 2020

A novel regulatory role of TRAPPC9 in L-plastin-mediated osteoclast actin ring formation.

Journal of cellular biochemistry

Hussein NJ,Mbimba T,Al-Adlaan AA,Ansari MY,Jaber FA,McDermott S,Kasumov T,Safadi FF

Wed Jan 01 00:00:00 UTC 2020

The TRAPP complex mediates secretion arrest induced by stress granule assembly.

The EMBO journal

Zappa F,Wilson C,Di Tullio G,Santoro M,Pucci P,Monti M,D'Amico D,Pisonero-Vaquero S,De Cegli R,Romano A,Saleem MA,Polishchuk E,Failli M,Giaquinto L,De Matteis MA

Tue Oct 01 00:00:00 UTC 2019

The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis.

The Journal of biological chemistry

Cuenca A,Insinna C,Zhao H,John P,Weiss MA,Lu Q,Walia V,Specht S,Manivannan S,Stauffer J,Peden AA,Westlake CJ

Fri Oct 18 00:00:00 UTC 2019

NIK‑ and IKKβ‑binding protein contributes to gastric cancer chemoresistance by promoting epithelial‑mesenchymal transition through the NF‑κB signaling pathway.

Oncology reports

Fu ZH,Liu SQ,Qin MB,Huang JA,Xu CY,Wu WH,Zhu LY,Qin N,Lai MY

Fri Jun 01 00:00:00 UTC 2018

NIK‑ and IKKβ‑binding protein contributes to gastric cancer chemoresistance by promoting epithelial‑mesenchymal transition through the NF‑κB signaling pathway.

Oncology reports

Fu ZH,Liu SQ,Qin MB,Huang JA,Xu CY,Wu WH,Zhu LY,Qin N,Lai MY

Fri Jun 01 00:00:00 UTC 2018

Knockdown of NIK and IKKβ-Binding Protein (NIBP) Reduces Colorectal Cancer Metastasis through Down-Regulation of the Canonical NF-κΒ Signaling Pathway and Suppression of MAPK Signaling Mediated through ERK and JNK.

PloS one

Qin M,Zhang J,Xu C,Peng P,Tan L,Liu S,Huang J

Mon Aug 14 00:00:00 UTC 2017

PloS one

Qin M,Zhang J,Xu C,Peng P,Tan L,Liu S,Huang J

Mon Aug 14 00:00:00 UTC 2017

PloS one

Qin M,Zhang J,Xu C,Peng P,Tan L,Liu S,Huang J

Mon Aug 14 00:00:00 UTC 2017

PloS one

Qin M,Zhang J,Xu C,Peng P,Tan L,Liu S,Huang J

Mon Aug 14 00:00:00 UTC 2017

NIK- and IKKβ-binding protein promotes colon cancer metastasis by activating the classical NF-κB pathway and MMPs.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Qin M,Liu S,Li A,Xu C,Tan L,Huang J,Liu S

Sun May 01 00:00:00 UTC 2016

NIK- and IKKβ-binding protein promotes colon cancer metastasis by activating the classical NF-κB pathway and MMPs.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Qin M,Liu S,Li A,Xu C,Tan L,Huang J,Liu S

Sun May 01 00:00:00 UTC 2016

NIK- and IKKβ-binding protein promotes colon cancer metastasis by activating the classical NF-κB pathway and MMPs.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Qin M,Liu S,Li A,Xu C,Tan L,Huang J,Liu S

Sun May 01 00:00:00 UTC 2016

NIK- and IKKβ-binding protein promotes colon cancer metastasis by activating the classical NF-κB pathway and MMPs.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Qin M,Liu S,Li A,Xu C,Tan L,Huang J,Liu S

Sun May 01 00:00:00 UTC 2016

Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome.

Proceedings of the National Academy of Sciences of the United States of America

Westlake CJ,Baye LM,Nachury MV,Wright KJ,Ervin KE,Phu L,Chalouni C,Beck JS,Kirkpatrick DS,Slusarski DC,Sheffield VC,Scheller RH,Jackson PK

Tue Feb 15 00:00:00 UTC 2011

Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome.

Proceedings of the National Academy of Sciences of the United States of America

Westlake CJ,Baye LM,Nachury MV,Wright KJ,Ervin KE,Phu L,Chalouni C,Beck JS,Kirkpatrick DS,Slusarski DC,Sheffield VC,Scheller RH,Jackson PK

Tue Feb 15 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: IKK2 binding protein; NIK and IKK(beta) binding protein; NIK and IKK-beta binding protein; NIK- and IKBKB-binding protein; Trafficking protein particle complex subunit 9; TRAPP 120 kDa subunit; Tularik gene 1 protein

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Gene Aliases: 1810044A24Rik; 2900005P22Rik; 4632408O18Rik; IBP; IKBKBBP; KIAA1882; mKIAA1882; MRT13; NIBP; T1; TRAPPC9; TRS120; TRS130

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UniProt ID: (Human) Q96Q05, (Mouse) Q3U0M1

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Entrez Gene ID: (Human) 83696, (Mouse) 76510

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Process(es)

cell differentiation cerebral cortex development neuron differentiation COPII vesicle coating positive regulation of NF-kappaB transcription factor activity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TRAPPC9 Polyclonal Antibody

TRAPPC9 Antibody (16014-1-AP) in ICC/IF

Product Details

16014-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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