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Proteintech
TRAT1 Polyclonal Antibody
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Product Details
13279-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TRAT1 Fusion Protein Ag4023 (30-186 aa encoded by BC025713)
Conjugate
Form
Liquid
Concentration
0.18 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ISHYVEKQR QDKMYSYSSD HTRVDEYYIE DTPIYGNLDD MISEPMDENC YEQMKARPEK SVNKMQEATP SAQATNETQM CYASLDHSVK GKRRKPRKQN THFSDKDGDE QLHAIDASVS KTTLVDSFSP ESQAVEENIH DDPIRLFGLI RAKREPIN (30-186 aa encoded by BC025713 )
Target Information
TRIM (T cell receptor-interacting molecule), also known as TRAT1 (T cell receptor associated transmembrane adaptor 1) is a 30 kDa protein expressed by T cells as a cystein-linked homodimer. It associates with TCR-CD3-zeta-chain complex and becomes phosphorylated by Src-family kinases. TRIM is potentially involved in negative regulation of TCR-mediated signaling, but its role remains unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: pp29/30; T cell receptor associated transmembrane adaptor 1; T cell receptor interacting molecule; T-cell receptor interacting molecule; T-cell receptor-associated transmembrane adapter 1; T-cell receptor-interacting molecule; TRIM
Gene Aliases: C030046M14Rik; HSPC062; pp29/30; TCRIM; TRAT1; TRIM
UniProt ID: (Human) Q6PIZ9, (Mouse) Q3UU67
Entrez Gene ID: (Human) 50852, (Mouse) 77647, (Rat) 498075
negative regulation of receptor recycling
immune system process
positive regulation of calcium-mediated signaling
positive regulation of T cell receptor signaling pathway
negative regulation of transport
adaptive immune response
cellular defense response
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
regulation of phosphatidylinositol 3-kinase signaling
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
T cell receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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