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NeoBiotechnologies
TRBP2/TARBP2 Monoclonal Antibody (PCRP-TARBP2-1E5)
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Product Details
6895-MSM1-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
PCRP-TARBP2-1E5
Immunogen
Recombinant full-length human TARBP2 protein
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
TRBP belongs to the family of dsRNA-binding proteins. It consists of highly conserved 2 dsRNA-binding domains and C-terminal basic region. It is a unique cellular protein capable of binding to HIV-TAR RNA and stimulates expression of HIV-1 long terminal repeats. It also inhibits the host antiviral and anti-proliferative mechanisms by directly binding to IFN-regulated dsRNA-dependent protein kinase (PKR). TRBP associates with Ago2 protein and forms an integral component of Dicer-containing complex. It has a role in micro RNA processing and in RISC assembly. Other functions of TRBP include promoting cellular growth and tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: RISC-loading complex subunit TARBP2; TAR (HIV) RNA binding protein 2; TAR (HIV) RNA-binding protein 2; TAR (HIV) RNA-binding protein TRBP1; TAR (HIV-1) RNA binding protein 2; TAR RNA binding protein 2; TAR RNA-binding protein 2; TARBP2; trans-activation responsive RNA-binding protein; Trans-activation-responsive RNA-binding protein
Gene Aliases: LOQS; TARBP2; TRBP; TRBP1; TRBP2
UniProt ID: (Human) Q15633
Entrez Gene ID: (Human) 6895
negative regulation of protein kinase activity
spermatid development
single fertilization
production of siRNA involved in RNA interference
targeting of mRNA for destruction involved in RNA interference
gene silencing by RNA
pre-miRNA processing
siRNA loading onto RISC involved in RNA interference
production of miRNAs involved in gene silencing by miRNA
multicellular organism growth
miRNA loading onto RISC involved in gene silencing by miRNA
positive regulation of viral genome replication
positive regulation of translation
regulation of viral transcription
negative regulation of defense response to virus by host
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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