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Proteintech
TRDN Polyclonal Antibody
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Product Details
26607-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: NFSASSIAKI GSDPLKLVRD AMEETTDWIY GFFSLLSDII SSEDEEDDDG DEDSDKGEID EPPLRKKEIH KDKTEKQEKP ERKIQTKVTH KEKEKGKEKV REKEKPEKKA THKEKIEKKE KPETKTVAKE QKKAKTAEKS EEKTKKEVKG GKQEKVKQTA AKVKEVQKTP SKPKEKEDKE KAAVSKHEQK GQSPAIPPPL PTEQASRPTP ASPALEGKY
Target Information
The junction between the transverse tubules (T-tubules) and the sarcoplasmic reticulum (SR) of skeletal muscle is called the triad. At the triad, dihydropyridine receptors (DHPR’s) of the T-tubule serve as voltage sensors in excitation-contraction coupling, while ryanodine receptors (RyR’s), the calcium release channels, exist in the membrane of the terminal cisternae of the SR. It is thought that during slow phase depolarization of the T-tubule, a third protein, triadin (MW 95 kDa) transmits electrochemical signals to the SR through direct interaction with both DHPR’s and RyR’s. Though its exact role in this signaling process is unclear, triadin has been shown to co-localize with both DHPR and RYR at the junctional face of the terminal cisternae.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cardiac triadin; Triadin; triadin 1; triadin 32 kDa (TRISK 32); triadin 49 kDa (TRISK 49); triadin 95
Gene Aliases: 2310045H21Rik; CPVT5; EG432451; TDN; TRDN; TRISK
UniProt ID: (Human) Q13061, (Rat) Q9QX75, (Mouse) E9Q9K5
Entrez Gene ID: (Human) 10345, (Rat) 59299, (Mouse) 76757
cellular calcium ion homeostasis
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
response to organic cyclic compound
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
myotube differentiation
cytoplasmic microtubule organization
negative regulation of release of sequestered calcium ion into cytosol
positive regulation of release of sequestered calcium ion into cytosol
heart contraction
endoplasmic reticulum membrane organization
muscle contraction
regulation of cell communication by electrical coupling
ion transmembrane transport
regulation of release of sequestered calcium ion into cytosol
negative regulation of ryanodine-sensitive calcium-release channel activity
positive regulation of ryanodine-sensitive calcium-release channel activity
regulation of cardiac muscle cell membrane potential
positive regulation of cell communication by electrical coupling involved in cardiac conduction
regulation of cardiac conduction
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