Invitrogen

TREM2 Polyclonal Antibody

TREM2 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 4

TREM2 Antibody (PA5-87933) in ICC/IF

Immunofluorescence analysis of TREM2 in NIH/3T3 cells. Samples were incubated with TREM2 Polyclonal antibody (Product # PA5-87933) using a dilution of 1:50 (40x lens). Blue: DAPI for nuclear staining.

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Product Details

PA5-87933

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:5,000

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

1:50-1:200

ELISA (ELISA)

1 µg/mL

in situ PLA (PLA)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 19-161 of human TREM2 (NP_0618381)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.85 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2804516

Product Specific Information

Immunogen sequence: HNTTVFQGVA GQSLQVSCPY DSMKHWGRRK AWCRQLGEKG PCQRVVSTHN LWLLSFLRRW NGSTAITDDT LGGTLTITLR NLQPHDAGLY QCQSLHGSEA DTLRKVLVEV LADPLDHRDA GDLWFPGESE SFEDAHVEHS ISR

Positive Samples: Mouse brain; Cellular Location: Cell membrane, Single-pass type I membrane protein

Target Information

TREM2 is a membrane protein that forms a receptor signaling complex with TYROBP. The encoded protein may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Epiisopiloturine, an Alkaloid from Pilocarpus microphyllus, Attenuates LPS-Induced Neuroinflammation by Interfering in the TLR4/NF-κB-MAPK Signaling Pathway in Microglial Cells.

Oxidative medicine and cellular longevity

de Sousa JAC,Azul FVCS,de Araújo AB,Tomé RC,Silva FRM,de Vasconcelos SMM,Rios FJ,Leal LKAM

PA5-87933 was used in Western Blotting to demonstrate the potent anti-inflammatory properties of EPI in microglial cells.

Tue May 09 00:00:00 UTC 2023

TREM2 mediates physical exercise-promoted neural functional recovery in rats with ischemic stroke via microglia-promoted white matter repair.

Journal of neuroinflammation

Xu J,Zhang L,Li M,He X,Luo J,Wu R,Hong Z,Zheng H,Hu X

PA5-87933 was used in Western Blotting to reveal a novel regenerative role of PE in white matter injury after stroke, which is mediated by upregulation of TREM2 and microglia-derived factor for oligodendrocytes regeneration.

Sat Feb 25 00:00:00 UTC 2023

LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions.

Molecular neurodegeneration

Zhao P,Xu Y,Jiang LL,Fan X,Ku Z,Li L,Liu X,Deng M,Arase H,Zhu JJ,Huang TY,Zhao Y,Zhang C,Xu H,Tong Q,Zhang N,An Z

PA5-87933 was used in Flow cytometry/Cell sorting to reveal the molecular mechanisms of LILRB2-mediated inhibition of TREM2 signaling in microglia and demonstrate a novel approach of enhancing TREM2-mediated microglia functions by blocking LILRB2-ligand interactions.

Sat Jun 18 00:00:00 UTC 2022

Bioinformatics

Protein Aliases: OTTHUMP00000039771; soluble TREM 2; soluble TREM2; sTREM 2; sTREM2; TREM; TREM-2; Triggering receptor expressed on monocytes 2; Triggering receptor expressed on myeloid cells; Triggering receptor expressed on myeloid cells 2; triggering receptor expressed on myeloid cells 2a; triggering receptor expressed on myeloid cells 2b; triggering receptor expressed on myeloid cells 2c

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Gene Aliases: TREM-2; TREM2; Trem2a; Trem2b; Trem2c

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UniProt ID: (Human) Q9NZC2, (Mouse) Q99NH8

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Entrez Gene ID: (Human) 54209, (Rat) 301227, (Mouse) 83433

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Function(s)

lipopolysaccharide binding receptor activity peptidoglycan binding lipoteichoic acid binding scaffold protein binding transmembrane signaling receptor activity protein binding

Process(es)

positive regulation of antigen processing and presentation of peptide antigen via MHC class II detection of lipopolysaccharide detection of peptidoglycan positive regulation of peptidyl-tyrosine phosphorylation positive regulation of calcium-mediated signaling positive regulation of ERK1 and ERK2 cascade detection of lipoteichoic acid cellular response to lipoteichoic acid cellular response to peptidoglycan dendritic cell differentiation positive regulation of protein localization to plasma membrane positive regulation of C-C chemokine receptor CCR7 signaling pathway positive regulation of CD40 signaling pathway phagocytosis, engulfment humoral immune response innate immune response regulation of immune response signal transduction lipopolysaccharide-mediated signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TREM2 Polyclonal Antibody

TREM2 Antibody (PA5-87933) in ICC/IF

Product Details

PA5-87933

Western Blot (WB)

Immunocytochemistry (ICC/IF)

ELISA (ELISA)

in situ PLA (PLA)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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