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Invitrogen
TREM2 Recombinant Rabbit Monoclonal Antibody (4H42L9)
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TREM2 Antibody (703422) in WB
Western blot was performed using Anti-TREM2 Rabbit Recombinant Monoclonal Antibody (Product # 703422). A 28 kDa (full length) and 55 kDa (glycosylated) band corresponding to TREM2 was observed across the cell lines tested. Membrane enriched extracts (30 µg lysate) and condition media of THP1 (Lane 1 and 2), THP1 differentiated to macrophage (lane 3 and 4), and THP1 differentiated to dendritic cells(Lane 5 and 6) were electrophoresed using Novex® NuPAGE® 12 % Bis-Tris gel (Product # NP0342BOX). Resolved proteins were then transferred onto a... View More
Product Details
703422
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
4H42L9
Immunogen
Protein corresponding to human TREM2 [aa19-aa134]
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2809235
Product Specific Information
This antibody is predicted to react with Monkey, Cat, Bovine, Sheep.
Target Information
TREM2 is a membrane protein that forms a receptor signaling complex with TYROBP. The encoded protein may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: OTTHUMP00000039771; soluble TREM 2; soluble TREM2; sTREM 2; sTREM2; TREM; TREM-2; Triggering receptor expressed on monocytes 2; Triggering receptor expressed on myeloid cells; Triggering receptor expressed on myeloid cells 2; triggering receptor expressed on myeloid cells 2a
Gene Aliases: TREM-2; TREM2; Trem2a; Trem2b; Trem2c
UniProt ID: (Human) Q9NZC2
Entrez Gene ID: (Human) 54209
positive regulation of antigen processing and presentation of peptide antigen via MHC class II
phagocytosis, engulfment
humoral immune response
detection of lipopolysaccharide
detection of peptidoglycan
innate immune response
positive regulation of peptidyl-tyrosine phosphorylation
regulation of immune response
positive regulation of calcium-mediated signaling
positive regulation of ERK1 and ERK2 cascade
detection of lipoteichoic acid
cellular response to lipoteichoic acid
cellular response to peptidoglycan
dendritic cell differentiation
positive regulation of protein localization to plasma membrane
positive regulation of C-C chemokine receptor CCR7 signaling pathway
positive regulation of CD40 signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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