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Product Details
24876-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TREX1 Fusion Protein Ag18325 (1-369 aa encoded by BC023630)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGPGARRQG RIVQGRPEMC FCPPPTPLPP LRILTLGTHT PTPCSSPGSA AGTYPTMGSQ ALPPGPMQTL IFFDMEATGL PFSQPKVTEL CLLAVHRCAL ESPPTSQGPP PTVPPPPRVV DKLSLCVAPG KACSPAASEI TGLSTAVLAA HGRQCFDDNL ANLLLAFLRR QPQPWCLVAH NGDRYDFPLL QAELAMLGLT SALDGAFCVD SITALKALER ASSPSEHGPR KSYSLGSIYT RLYGQSPPDS HTAEGDVLAL LSICQWRPQA LLRWVDAHAR PFGTIRPMYG VTASARTKPR PSAVTTTAHL ATTRNTSPSL GESRGTKDLP PVKDPGALSR EGLLAPLGLL AILTLAVATL YGLSLATPGE (1-369 aa encoded by BC023630)
Target Information
Trex1 (ATRIP) is the major human 3' to 5' exonuclease which is required for checkpoint signaling after DNA damage. It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress. Trex1 is required for ATR expression. This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3' to 5' exonuclease activity and may be a subunit of human DNA polymerase III. Multiple transcript variants encoding different isoforms have been found. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 3' repair exonuclease 1; 3'-5' exonuclease TREX1; Deoxyribonuclease III; DNase III; Three-prime repair exonuclease 1
Gene Aliases: AGS1; CRV; DRN3; HERNS; TREX1
UniProt ID: (Human) Q9NSU2
Entrez Gene ID: (Human) 11277
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