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Invitrogen
TRF1 Monoclonal Antibody (57-6)
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Product Details
MA1-46375
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Published species
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
57-6
Immunogen
Recombinant TRF-1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
TBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2203360
Product Specific Information
This antibody will not work in ICC/IF applications.
Suggested positive control: HeLa nuclear extracts, antigen standard for TERF1 (transient overexpression lysate), Hela whole cell extract.
Target Information
This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ41416; NIMA-interacting protein 2; Telomeric protein Pin2/TRF1; telomeric repeat binding factor (NIMA-interacting) 1; telomeric repeat binding factor 1; Telomeric repeat-binding factor 1; TTAGGG repeat-binding factor 1
Gene Aliases: hTRF1-AS; PIN2; t-TRF1; TERF1; TRBF1; TRF; TRF1
UniProt ID: (Human) P54274, (Mouse) P70371
Entrez Gene ID: (Human) 7013, (Rat) 297758, (Mouse) 21749
DNA binding
double-stranded telomeric DNA binding
telomerase activity
protein binding
DNA binding, bending
telomeric DNA binding
protein homodimerization activity
ubiquitin binding
G-rich strand telomeric DNA binding
molecular_function
chromatin binding
microtubule binding
protein heterodimerization activity
telomere maintenance
telomere maintenance via telomerase
mitotic nuclear division
negative regulation of DNA replication
telomere capping
telomeric loop formation
negative regulation of telomere maintenance via telomerase
negative regulation of telomere maintenance via semi-conservative replication
response to drug
meiotic telomere clustering
cell division
negative regulation of telomerase activity
positive regulation of telosome assembly
negative regulation of establishment of protein localization to telomere
negative regulation of establishment of RNA localization to telomere
negative regulation of establishment of macromolecular complex localization to telomere
G2/M transition of mitotic cell cycle
obsolete age-dependent telomere shortening
mitotic spindle assembly checkpoint
obsolete telomere maintenance via telomere shortening
positive regulation of microtubule polymerization
positive regulation of apoptotic process
positive regulation of mitotic nuclear division
positive regulation of mitotic cell cycle
protein homooligomerization
cell cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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