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TRHR1 Antibody (ATR-005-200UL) in ICC/IF
Expression of Thyrotropin-releasing hormone receptor 1 in mouse MS1 cells - Immunocytochemical staining of mouse pancreatic islet endothelial (MS1) cells. Cells were stained using Anti-TRHR1 Antibody (#ATR-005) followed by goat- Anti-rabbit-AlexaFluor-594 secondary Antibody (red). Nuclear staining was demonstrated using DAPI as the counterstain (blue).
Product Details
ATR-005-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CKQKPTEKAANYS, corresponding to amino acid residues 336-349 of rat Thyrotropin-releasing hormone receptor 1, Intracellular, C-terminus
Conjugate
Form
Lyophilized
Concentration
0.75 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
TRH-R is a 398 amino acid integral membrane protein with six transmembrane domains and belongs to G-protein coupled receptor 1 family. It acts as a receptor for the signaling hormone TRH and activates the inositol phospholipid-calcium-protein kinase C transduction pathway upon binding with TRH. Reports suggest that TRH-R is a neurotransmitter and neuro regulator that controls dimerization of the TRH receptor and potentiates hormone-induced receptor trafficking. It is known to widely express in the thyrotroph cells of the anterior pituitary.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC141920; Thyroliberin receptor; Thyrotropin-releasing hormone receptor; TRH receptor; TRH-R; TRH1 Receptor
Gene Aliases: TRH-R; TRH-R1; TRHR
UniProt ID: (Human) P34981, (Rat) Q01717, (Mouse) P21761
Entrez Gene ID: (Human) 7201, (Rat) 25570, (Mouse) 22045
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