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Proteintech
TRIB2 Monoclonal Antibody (1A10A6), CoraLite® Plus 488
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Product Details
CL488-67171
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1A10A6
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MNIHRSTPIT IARYGRSRNK TQDFEELSSI RSAEPSQSFS PNLGSPSPPE TPNLSHCVSC IGKYLLLEPL EGDHVFRAVH LHSGEELVCK VFDISCYQES LAPCFCLSAH SNINQITEII LGETKAYVFF ERSYGDMHSF VRTCKKLREE EAARLFYQIA SAVAHCHDGG LVLRDLKLRK FIFKDEERTR VKLESLEDAY ILRGDDDSLS DKHGCPAYVS PEILNTSGSY SGKAADVWSL GVMLYTMLVG RYPFHDIEPS SLFSKIRRGQ FNIPETLSPK AKCLIRSILR REPSERLTSQ EILDHPWFST DFSVSNSAYG AKEVSDQLVP DVNMEENLDP FFN
Target Information
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: TRB-2; TRIB2; TRIB2 (HGNC:30809); Tribbles homolog 2
Gene Aliases: AW319517; C5FW; GS3955; TRB-2; TRB2; TRIB2
UniProt ID: (Human) Q92519, (Mouse) Q8K4K3
Entrez Gene ID: (Human) 28951, (Mouse) 217410
nucleotide binding
protein kinase activity
protein kinase inhibitor activity
transcription factor binding
mitogen-activated protein kinase kinase binding
ubiquitin protein ligase binding
ubiquitin-protein transferase regulator activity
ATP binding
transferase activity, transferring phosphorus-containing groups
protein phosphorylation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of MAP kinase activity
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of interleukin-10 biosynthetic process
negative regulation of fat cell differentiation
regulation of catalytic activity
positive regulation of ubiquitin-protein transferase activity
negative regulation of protein kinase activity
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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