Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
TRIB3 Monoclonal Antibody (2C10C7)
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
66702-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2C10C7
Immunogen
TRIB3 Fusion Protein Ag25776 (1-358 aa encoded by BC027484)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MRATPLAAP AGSLSRKKRL ELDDNLDTER PVQKRARSGP QPRLPPCLLP LSPPTAPDRA TAVATASRLG PYVLLEPEEG GRAYRALHCP TGTEYTCKVY PVQEALAVLE PYARLPPHKH VARPTEVLAG TQLLYAFFTR THGDMHSLVR SRHRIPEPEA AVLFRQMATA LAHCHQHGLV LRDLKLCRFV FADRERKKLV LENLEDSCVL TGPDDSLWDK HACPAYVGPE ILSSRASYSG KAADVWSLGV ALFTMLAGHY PFQDSEPVLL FGKIRRGAYA LPAGLSAPAR CLVRCLLRRE PAERLTATGI LLHPWLRQDP MPLAPTRSHL WEAAQVVPDG LGLDEAREEE GDREVVLYG (1-358 aa encoded by BC027484 )
Target Information
A novel inhibitor of cell division, Tribbles, blocks mitosis at a critical point in Drosophila morphogenesis. Recently, mammalian homologues of Tribbles (Trbs) have been identified that control mitogen-activated protein kinase (MAPK) activity. TRIB3 also known as TRB-3, SINK, and SKIP3 is a member of Trbs family. Overexpression of this protein inhibits NF-kB-dependent transcription induced by tumor necrosis factor (TNF) stimulation or its downstream signaling proteins but does not inhibit NF-kB translocation to the nucleus and binding to DNA. TRIB3/SKIP3 is also overexpressed in multiple human tumors and is regulated by hypoxia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DJ1103G7.3; induced in fatty liver dystrophy 2; kinase; Neuronal cell death Inducible Putative Kinase; Neuronal cell death-inducible putative kinase; p65-interacting inhibitor of NF-kappa-B; p65-interacting inhibitor of NF-kappaB; SINK; TRB-3; Tribbles 3; Tribbles homolog 3
Gene Aliases: C20orf97; Ifld2; NIPK; SINK; SKIP3; TRB-3; TRB3; TRIB3
UniProt ID: (Human) Q96RU7, (Mouse) Q8K4K2, (Rat) Q9WTQ6
Entrez Gene ID: (Human) 57761, (Mouse) 228775, (Rat) 246273
transcription corepressor activity
protein kinase inhibitor activity
protein binding
ATP binding
kinase activity
protein kinase binding
mitogen-activated protein kinase kinase binding
ubiquitin protein ligase binding
ubiquitin-protein transferase regulator activity
protein kinase activity
transferase activity, transferring phosphorus-containing groups
enzyme binding
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
negative regulation of protein kinase activity
apoptotic process
regulation of glucose transport
positive regulation of protein binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
cellular response to insulin stimulus
response to endoplasmic reticulum stress
regulation of MAP kinase activity
negative regulation of fat cell differentiation
negative regulation of fatty acid biosynthetic process
positive regulation of protein catabolic process
negative regulation of transcription, DNA-templated
positive regulation of ubiquitin-protein transferase activity
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
negative regulation of nucleic acid-templated transcription
programmed cell death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support