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Invitrogen
TRIF Polyclonal Antibody
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TRIF Antibody (PA5-23467) in IHC (P)
Immunohistochemical analysis of TRIF in formalin-fixed paraffin-embedded tissue section of mouse spleen. Samples were incubated in TRIF polyclonal antibody (Product # PA5-23467) using a dilution of 1:200 followed by HRP labeled anti-rabbit secondary antibody and DAB reagent. Nuclei of cells were counter-stained with hematoxylin.
Product Details
PA5-23467
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Pig,
Rat,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide made to an internal portion of the mouse TRIF protein (between amino acids 100-180) [UniProt Q80UF7].
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2540967
Product Specific Information
Suggested positive control: antigen standard for TICAM1 (transient overexpression lysate), mouse spleen tissue or mouse spleen protein.
Target Information
Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: hCG_39321; HSD34; RNF36; TI; TICAM-1; TIR domain-containing adapter molecule 1; TIR domain-containing adapter protein inducing IFN-beta; TIR domain-containing adaptor inducing interferon-beta; toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; toll-like receptor adaptor molecule 1
Gene Aliases: AW046014; AW547018; TICAM-1; Ticam1; TRIF
UniProt ID: (Mouse) Q80UF7
Entrez Gene ID: (Mouse) 106759, (Rat) 363328
macrophage activation involved in immune response
immune system process
MyD88-independent toll-like receptor signaling pathway
apoptotic process
inflammatory response
signal transduction
positive regulation of B cell proliferation
positive regulation of protein ubiquitination
lipopolysaccharide-mediated signaling pathway
positive regulation of protein binding
positive regulation of type I interferon production
response to lipopolysaccharide
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
positive regulation of natural killer cell activation
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to exogenous dsRNA
regulation of protein homodimerization activity
positive regulation of chemokine biosynthetic process
innate immune response
positive regulation of interferon-beta biosynthetic process
positive regulation of nitric oxide biosynthetic process
positive regulation of B cell activation
positive regulation of NF-kappaB transcription factor activity
defense response to virus
apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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