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Invitrogen
TRIM Polyclonal Antibody
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Product Details
PA5-51706
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TRIM. Recombinant protein control fragment (Product #RP-102133).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2648908
Product Specific Information
Immunogen sequence: RQDKMYSYSS DHTRVDEYYI EDTPIYGNLD DMISEPMDEN CYEQMKARPE KSVNKMQEAT PSAQATNETQ MCYASLDHSV KGKRRKPRKQ NTHFSDKDGD EQLHAI
Highest antigen sequence identity to the following orthologs: Mouse - 62%, Rat - 58%.
Target Information
TRIM (T cell receptor-interacting molecule), also known as TRAT1 (T cell receptor associated transmembrane adaptor 1) is a 30 kDa protein expressed by T cells as a cystein-linked homodimer. It associates with TCR-CD3-zeta-chain complex and becomes phosphorylated by Src-family kinases. TRIM is potentially involved in negative regulation of TCR-mediated signaling, but its role remains unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: pp29/30; T cell receptor interacting molecule; T-cell receptor-associated transmembrane adapter 1; T-cell receptor-interacting molecule; TRIM
Gene Aliases: HSPC062; pp29/30; TCRIM; TRAT1; TRIM
UniProt ID: (Human) Q6PIZ9
Entrez Gene ID: (Human) 50852
negative regulation of receptor recycling
adaptive immune response
cellular defense response
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
regulation of phosphatidylinositol 3-kinase signaling
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
positive regulation of calcium-mediated signaling
T cell receptor signaling pathway
positive regulation of T cell receptor signaling pathway
negative regulation of transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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