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Invitrogen
TRIM Monoclonal Antibody (TRIM-04), PE
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FIGURE: 1 / 5
TRIM Antibody (MA1-19651) in Flow
Comparison of anti-TRIM (TRIM-04) PE Monoclonal antibody (Product # MA1-19651) nonspecific intracellular staining (red) and mouse IgG2a Isotype control (MOPC-173) PE antibody nonspecific intracellular staining (concentration in sample 5 µg/mL, same as anti-TRIM PE concentration, blue) co-stained by anti-mouse CD3 (145-2C11) APC antibody (concentration in sample 1.2 µg/mL) in flow cytometry analysis of murine splenocyte suspension. Clone TRIM-04 is not specific for murine TRIM.
Product Details
MA1-19651
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
TRIM-04
Immunogen
Recombinant intracellular domain (aa 29-186) of human TRIM.
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Purification
Size-exclusion chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2208279
Product Specific Information
This antibody recognizes an intracellular epitope of T cell receptor-interacting molecule (TRIM), a 30 kDa adaptor protein expressed by T cells.
This antibody will not cross-react with mouse.
Target Information
TRIM (T cell receptor-interacting molecule), also known as TRAT1 (T cell receptor associated transmembrane adaptor 1) is a 30 kDa protein expressed by T cells as a cystein-linked homodimer. It associates with TCR-CD3-zeta-chain complex and becomes phosphorylated by Src-family kinases. TRIM is potentially involved in negative regulation of TCR-mediated signaling, but its role remains unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: pp29/30; T cell receptor interacting molecule; T-cell receptor-associated transmembrane adapter 1; T-cell receptor-interacting molecule; TRIM
Gene Aliases: HSPC062; pp29/30; TCRIM; TRAT1; TRIM
UniProt ID: (Human) Q6PIZ9
Entrez Gene ID: (Human) 50852
negative regulation of receptor recycling
adaptive immune response
cellular defense response
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
regulation of phosphatidylinositol 3-kinase signaling
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
positive regulation of calcium-mediated signaling
T cell receptor signaling pathway
positive regulation of T cell receptor signaling pathway
negative regulation of transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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