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Invitrogen
TRIM22 Monoclonal Antibody (OTI1D3)
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TRIM22 Antibody (MA5-26093) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded human tonsil tissue. To expose target proteins, 10mM citric buffer, pH6.0, 120°C for 3min was used. Following antigen retrieval, tissues were probed with a TRIM22 monoclonal antibody (Product # MA5-26093).
Product Details
MA5-26093
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI1D3
Immunogen
Human recombinant protein fragment corresponding to amino acids 61-406 of TRIM22 produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2723733
Target Information
TRIM22 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. It localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 50 kDa-stimulated trans-acting factor; E3 ubiquitin-protein ligase TRIM22; RING finger protein 94; RING-type E3 ubiquitin transferase TRIM22; Staf-50; stimulated trans-acting factor (50 kDa); tripartite binding motif 22; tripartite motif protein TRIM22; tripartite motif-containing 22; Tripartite motif-containing protein 22
Gene Aliases: GPSTAF50; RNF94; STAF50; TRIM22
UniProt ID: (Human) Q8IYM9
Entrez Gene ID: (Human) 10346
transcription, DNA-templated
regulation of transcription, DNA-templated
immune response
response to virus
positive regulation of autophagy
protein ubiquitination
regulation of protein localization
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
defense response to virus
interferon-gamma-mediated signaling pathway
protein trimerization
negative regulation of nucleic acid-templated transcription
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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