Proteintech

TRIM24 Monoclonal Antibody (1D6D9)

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Datasheet
Protocols
Questions & Answers

Product Details

66324-1-IG

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1D6D9

Immunogen

TRIM24 Fusion Protein Ag5417 (701-1050 aa encoded by BC028689)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SKPAGADST HKVPVVMLEP IRIKQENSGP PENYDFPVVI VKQESDEESR PQNANYPRSI LTSLLLNSSQ SSTSEETVLR SDAPDSTGDQ PGLHQDNSSN GKSEWLDPSQ KSPLHVGETR KEDDPNEDWC AVCQNGGELL CCEKCPKVFH LSCHVPTLTN FPSGEWICTF CRDLSKPEVE YDCDAPSHNS EKKKTEGLVK LTPIDKRKCE RLLLFLYCHE MSLAFQDPVP LTVPDYYKII KNPMDLSTIK KRLQEDYSMY SKPEDFVADF RLIFQNCAEF NEPDSEVANA GIKLENYFEE LLKNLYPEKR FPKPEFRNES EDNKFSDDSD DDFVQPRKKR LKSIEERQLL K (701-1050 aa encoded by BC028689)

Target Information

The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Ab2-427; E3 ubiquitin-protein ligase TRIM24; RING finger protein 82; RING-type E3 ubiquitin transferase TIF1-alpha; TIF1-alpha; Transcription intermediary factor 1-alpha; transcriptional intermediary factor 1; transcriptional intermediary factor 1, alpha; tripartite motif-containing 24; Tripartite motif-containing protein 24

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Gene Aliases: A130082H20Rik; AI447469; D430004I05Rik; hTIF1; PTC6; RNF82; TF1A; TIF1; TIF1-alpha; TIF1A; TIF1ALPHA; TRIM24

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UniProt ID: (Human) O15164, (Mouse) Q64127

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Entrez Gene ID: (Human) 8805, (Rat) 500084, (Mouse) 21848

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Function(s)
p53 binding chromatin binding transcription coactivator activity protein tyrosine kinase activity ubiquitin-protein transferase activity receptor binding protein binding zinc ion binding ligase activity ligand-dependent nuclear receptor binding estrogen response element binding methylated histone binding sequence-specific DNA binding ubiquitin protein ligase activity lysine-acetylated histone binding molecular_function protein kinase activity DNA binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity
Process(es)
protein phosphorylation negative regulation of cell proliferation positive regulation of gene expression protein ubiquitination protein catabolic process regulation of protein stability regulation of apoptotic process response to peptide hormone negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated protein autophosphorylation calcium ion homeostasis regulation of vitamin D receptor signaling pathway cellular response to estrogen stimulus regulation of signal transduction by p53 class mediator transcription from RNA polymerase II promoter peptidyl-tyrosine phosphorylation transcription, DNA-templated regulation of transcription, DNA-templated regulation of nucleic acid-templated transcription
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