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Invitrogen
TRIM24 Monoclonal Antibody (OTI2D9)
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TRIM24 Antibody (MA5-26554) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of human ovary tissue. To expose target proteins, 10mM citric buffer, pH6.0, 120°C for 3min was used. Following antigen retrieval, tissues were probed with a TRIM24 monoclonal antibody (Product # MA5-26554).
Product Details
MA5-26554
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI2D9
Immunogen
Human recombinant protein fragment corresponding to amino acids 706-1016 of TRIM24 produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2725566
Target Information
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase TRIM24; RING finger protein 82; RING-type E3 ubiquitin transferase TIF1-alpha; TIF1-alpha; Transcription intermediary factor 1-alpha; transcriptional intermediary factor 1; tripartite motif-containing 24; Tripartite motif-containing protein 24
Gene Aliases: hTIF1; PTC6; RNF82; TF1A; TIF1; TIF1A; TIF1ALPHA; TRIM24
UniProt ID: (Human) O15164
Entrez Gene ID: (Human) 8805
p53 binding
chromatin binding
transcription coactivator activity
protein tyrosine kinase activity
ubiquitin-protein transferase activity
receptor binding
protein binding
zinc ion binding
ligase activity
ligand-dependent nuclear receptor binding
estrogen response element binding
methylated histone binding
sequence-specific DNA binding
ubiquitin protein ligase activity
lysine-acetylated histone binding
transcription from RNA polymerase II promoter
negative regulation of cell proliferation
protein ubiquitination
peptidyl-tyrosine phosphorylation
protein catabolic process
regulation of protein stability
regulation of apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
protein autophosphorylation
calcium ion homeostasis
regulation of vitamin D receptor signaling pathway
cellular response to estrogen stimulus
regulation of signal transduction by p53 class mediator
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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