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Invitrogen
TRIM30 Polyclonal Antibody
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Product Details
PA5-20591
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 24 amino acid peptide near the amino terminus of the mouse TRIM30.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11155233
Product Specific Information
A suggested positive control is mouse heart tissue lysate.
PA5-20591 can be used with blocking peptide PEP-0711.
Target Information
TRIM30 belongs to a family of the tripartite motif (TRIM) proteins involved in the regulation of cell proliferation, differentiation, development, oncogenesis, apoptosis and antiviral responses. The TRIM protein family is an expanding family of RING ('really interesting new gene') proteins, also known as RBCC proteins as they contain an RBCC motif, which comprises a RING domain, one or two B-boxes and a predicted coiled-coil region. Studies have shown that some TRIM family members are critical to innate immunity; TRIM5, TRIM19 and TRIM25, for example, have been shown to restrict viral infection. A recent study shows that TRIM30 functions as a negative modulator of the TLR signaling pathway, by targeting TAB2 and TAB3, and contributes to the inhibition of TLR-mediated NF-kappa-B activation. The importance of TRIM30 in the attenuation or termination of NF-kappa-B activation suggests that targeting of TAB2 and TAB3 by TRIM30alpha may be a mechanism for modulating many types of immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Down regulatory protein of interleukin-2 receptor; regulatory protein, T lymphocyte 1; tripartite motif protein 30; tripartite motif-containing 30; Tripartite motif-containing protein 30; Tripartite motif-containing protein 30A
Gene Aliases: RGD1563970; Rpt-1; Rpt1; Trim30; Trim30a
UniProt ID: (Mouse) P15533
Entrez Gene ID: (Rat) 499223, (Mouse) 20128
transcription, DNA-templated
regulation of transcription, DNA-templated
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
negative regulation of toll-like receptor signaling pathway
positive regulation of protein catabolic process
positive regulation of viral entry into host cell
protein autoubiquitination
negative regulation of NLRP3 inflammasome complex assembly
negative regulation of reactive oxygen species metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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