Abnova

TRIM32 Monoclonal Antibody (2E5)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

H00022954-M09

Applications
Tested Dilution
Publications

Western Blot (WB)

1-5 µg/mL
-

Immunocytochemistry (ICC/IF)

10-100 µg/mL
-

ELISA (ELISA)

10 µg/mL
-

Functional Assay (Functional)

1-5 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

2E5

Immunogen

TRIM32 (NP_036342, 105 a.a. approximately 204 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

Product Specific Information

Product may be used with Western Blot (Transfected lysate).

Immunogen sequence: RRLPRQFCRS CGLVLCEPCR EADHQPPGHC TLPVKEAAEE RRRDFGEKLT RLRELMGELQ RRKAALEGVS KDLQARYKAV LQEYGHEERR VQDELARSRK

Target Information

TRIM32 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. TRIM32 localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 72 kDa Tat-interacting protein; E3 ubiquitin-protein ligase TRIM32; RING-type E3 ubiquitin transferase TRIM32; RP11-67K19.1; TAT-interactive protein, 72-KD; tripartite motif-containing 32; Tripartite motif-containing protein 32; Zinc finger protein HT2A; zinc-finger protein HT2A

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Gene Aliases: BBS11; HT2A; LGMD2H; TATIP; TRIM32

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UniProt ID: (Human) Q13049

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Entrez Gene ID: (Human) 22954

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Function(s)
transcription coactivator activity RNA binding ubiquitin-protein transferase activity protein binding zinc ion binding ligase activity myosin binding Tat protein binding translation initiation factor binding ubiquitin binding protein self-association ubiquitin protein ligase activity
Process(es)
protein polyubiquitination tissue homeostasis actin ubiquitination response to UV protein ubiquitination positive regulation of cell growth positive regulation of cell migration regulation of type I interferon production negative regulation of viral transcription response to tumor necrosis factor protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response fat cell differentiation positive regulation of neuron differentiation positive regulation of protein catabolic process positive regulation of cell cycle positive regulation of proteolysis muscle cell cellular homeostasis negative regulation of fibroblast proliferation positive regulation of neurogenesis positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of striated muscle cell differentiation axon development negative regulation of viral release from host cell negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of tumor necrosis factor-mediated signaling pathway positive regulation of interleukin-17-mediated signaling pathway positive regulation of chemokine (C-C motif) ligand 20 production positive regulation of cell motility
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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