Invitrogen

TRIM47 Polyclonal Antibody

1 Published Figure

3 References

View all (3) TRIM47 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (2)
Published Figures (1)

TRIM47 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 3

TRIM47 Antibody (PA5-50892) in IHC (P)

Immunohistochemical analysis of TRIM47 in paraffin embedded Human esophagus cancer tissue using TRIM47 Polyclonal Antibody (Product # PA5-50892) at a 1:30 dilution.

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Product Details

PA5-50892

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:25-1:100

In vitro Assay (IV)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to a region derived from internal residues of human tripartite motif containing 47

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.9 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 40% glycerol

Contains

0.05% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2636344

Product Specific Information

The antibody detects endogenous levels of total TRIM47 protein.

Target Information

E3 ubiquitin-protein ligase that mediates the ubiquitination and proteasomal degradation of CYLD. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate.

Brain : a journal of neurology

Mishra A,Duplaà C,Vojinovic D,Suzuki H,Sargurupremraj M,Zilhão NR,Li S,Bartz TM,Jian X,Zhao W,Hofer E,Wittfeld K,Harris SE,van der Auwera-Palitschka S,Luciano M,Bis JC,Adams HHH,Satizabal CL,Gottesman RF,Gampawar PG,Bülow R,Weiss S,Yu M,Bastin ME,Lopez OL,Vernooij MW,Beiser AS,Völker U,Kacprowski T,Soumare A,Smith JA,Knopman DS,Morris Z,Zhu Y,Rotter JI,Dufouil C,Valdés Hernández M,Muñoz Maniega S,Lathrop M,Boerwinkle E,Schmidt R,Ihara M,Mazoyer B,Yang Q,Joutel A,Tournier-Lasserve E,Launer LJ,Deary IJ,Mosley TH,Amouyel P,DeCarli CS,Psaty BM,Tzourio C,Kardia SLR,Grabe HJ,Teumer A,van Duijn CM,Schmidt H,Wardlaw JM,Ikram MA,Fornage M,Gudnason V,Seshadri S,Matthews PM,Longstreth WT,Couffinhal T,Debette S

PA5-50892 was used in Immunohistochemistry (Paraffin), Western Blot, In Vitro Assay to present a comprehensive gene-mapping study and preliminary functional evaluation suggesting a putative role of TRIM47 in the pathophysiology of cerebral small vessel disease, making it an important candidate for extensive in vivo explorations and future translational work.

Thu Jun 30 00:00:00 UTC 2022

Ubiquitination and degradation of NF90 by Tim-3 inhibits antiviral innate immunity.

eLife

Dou S,Li G,Li G,Hou C,Zheng Y,Tang L,Gao Y,Mo R,Li Y,Wang R,Shen B,Zhang J,Han G

PA5-50892 was used in Western Blot to provide insights into the crosstalk between Tim-3 and other receptors in antiviral innate immunity and its related clinical significance.

Thu Jun 10 00:00:00 UTC 2021

Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia.

The Journal of experimental medicine

Tang J,Tu S,Lin G,Guo H,Yan C,Liu Q,Huang L,Tang N,Xiao Y,Pope RM,Rajaram MVS,Amer AO,Ahmer BM,Gunn JS,Wozniak DJ,Tao L,Coppola V,Zhang L,Langdon WY,Torrelles JB,Lipkowitz S,Zhang J

PA5-50892 was used in Western Blotting to show the NLRP3 inflammasome is regulated from causing endotoxemia by K63- and K48-linked ubiquitination.

Mon Apr 06 00:00:00 UTC 2020

Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia.

The Journal of experimental medicine

Tang J,Tu S,Lin G,Guo H,Yan C,Liu Q,Huang L,Tang N,Xiao Y,Pope RM,Rajaram MVS,Amer AO,Ahmer BM,Gunn JS,Wozniak DJ,Tao L,Coppola V,Zhang L,Langdon WY,Torrelles JB,Lipkowitz S,Zhang J

PA5-50892 was used in Western Blotting to show the NLRP3 inflammasome is regulated from causing endotoxemia by K63- and K48-linked ubiquitination.

Mon Apr 06 00:00:00 UTC 2020

Bioinformatics

Protein Aliases: E3 ubiquitin-protein ligase TRIM47; Gene overexpressed in astrocytoma protein; RING finger protein 100; tripartite motif protein 47; tripartite motif-containing 47; Tripartite motif-containing protein 47

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Gene Aliases: 2210023F24Rik; GOA; RNF100; TRIM47

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UniProt ID: (Human) Q96LD4, (Mouse) Q8C0E3

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Entrez Gene ID: (Human) 91107, (Mouse) 217333

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Function(s)

zinc ion binding metal ion binding

Process(es)

biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TRIM47 Polyclonal Antibody

TRIM47 Antibody (PA5-50892) in IHC (P)

Product Details

PA5-50892

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

In vitro Assay (IV)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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