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Product Details
BS-9165R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human TRIM6.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
TRIM6 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified.The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. A read-through transcript transcribed from this gene and TRIM34 has been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: RING finger protein 89; RING-type E3 ubiquitin transferase TRIM6; tripartite motif protein 6; tripartite motif-containing 6; Tripartite motif-containing protein 6
Gene Aliases: C430046K18Rik; D7Ertd684e; RNF89; TRIM6
UniProt ID: (Human) Q9C030, (Mouse) Q8BGE7
Entrez Gene ID: (Human) 117854, (Rat) 293294, (Mouse) 94088
biological_process
protein trimerization
protein polyubiquitination
positive regulation of defense response to virus by host
positive regulation of cytokine secretion involved in immune response
positive regulation of gene expression
negative regulation of gene expression
positive regulation of peptidyl-threonine phosphorylation
free ubiquitin chain polymerization
response to lipopolysaccharide
positive regulation of peptidyl-serine phosphorylation
cellular response to interferon-beta
negative regulation of viral genome replication
negative regulation of transcription, DNA-templated
positive regulation of type I interferon-mediated signaling pathway
cellular response to virus
regulation of NIK/NF-kappaB signaling
positive regulation of transcription regulatory region DNA binding
negative regulation of stem cell differentiation
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