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Product Details
PA5-58266
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TRIM71. Recombinant protein control fragment (Product #RP-96488).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2648947
Product Specific Information
Immunogen sequence: QSEVKAVTAR HKKALEEREC ELLWKVEKIR QVKAKSLYLQ VEKLRQNLNK LESTISAVQQ VLEEGRALDI LLARDRMLAQ VQELKTVRSL LQPQEDDRVM
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 98%.
Target Information
TRIM71 is the mammalian ortholog to the C. elegans heterochronic protein Lin41, a protein that is thought to be important in postembryonic development, and is genetically and biochemically downstream of both Shh and Fgf signaling pathways. Similar to its C. elegans homolog, TRIM71 is a target of the microRNA let-7 and is likely to play a role in mammalian development. Recent experiments have indicated that TRIM71 is an E3 ubiquitin ligase and can interact with the Dicer and the Argonaute proteins Ago1, Ago2, and Ago4. Overexpression and depletion of TRIM71 led to inverse changes in Ago2 protein levels, suggesting TRIM71 can regulate Ago2 turnover. Finally, TRIM71 cooperates with the pluripotency factor Lin-28 in regulating let-7.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: abnormal cell LINeage LIN-41; E3 ubiquitin-protein ligase TRIM71; homolog of C. elegans Lin-41; Protein lin-41 homolog; RING-type E3 ubiquitin transferase TRIM71; tripartite motif containing 71, E3 ubiquitin protein ligase; tripartite motif-containing 71; Tripartite motif-containing protein 71
Gene Aliases: LIN-41; LIN41; TRIM71
UniProt ID: (Human) Q2Q1W2
Entrez Gene ID: (Human) 131405
G1/S transition of mitotic cell cycle
neural tube closure
fibroblast growth factor receptor signaling pathway
miRNA metabolic process
negative regulation of translation
neural tube development
miRNA mediated inhibition of translation
protein autoubiquitination
regulation of gene silencing by miRNA
3'-UTR-mediated mRNA destabilization
stem cell proliferation
regulation of neural precursor cell proliferation
positive regulation of gene silencing by miRNA
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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