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Invitrogen
TRIM72 Recombinant Rabbit Monoclonal Antibody (HL1853)
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Product Details
MA5-47200
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
HL1853
Immunogen
Recombinant fragment of human TRIM72.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2938272
Product Specific Information
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
Target Information
Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Mg53; mitsugumin 53; Mitsugumin-53; TRIM72; trim72 {ECO:0000250|UniProtKB:Q8N4X6}; tripartite motif containing 72, E3 ubiquitin protein ligase; tripartite motif-containing 72; Tripartite motif-containing protein 72
Gene Aliases: BC067209; MG53; RGD1562778; TRIM72
UniProt ID: (Human) Q6ZMU5, (Mouse) Q1XH17, (Rat) A0JPQ4
Entrez Gene ID: (Human) 493829, (Mouse) 434246, (Rat) 365377
plasma membrane repair
muscle system process
exocytosis
muscle contraction
muscle organ development
negative regulation of myotube differentiation
protein ubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of insulin-like growth factor receptor signaling pathway
negative regulation of insulin receptor signaling pathway
protein homooligomerization
transport
membrane budding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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