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Product Details
PA5-53996
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TFG. Recombinant protein control fragment (Product #RP-92560).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2648412
Product Specific Information
Immunogen sequence: PQQLPAQPPQ QYQASNYPAQ TYTAQTSQPT NYTVAPASQP GMAPSQPGAY QPRPGFTSLP GSTMTPPPSG PNPYARNRPP FGQGYTQPG
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 85%.
Target Information
TFG protein, a recently identified novel protein, is a human homolog of mouse TFG protein. It contains an N-terminal coiled-coil structure, a SPYGQ-rich region followed by octicosapeptide repeats. Research shows that TFG can modulate SHP-1 activity and is a novel member of the NF-kB pathway. The physiological functions of this protein remain largely elusive, but TFG is thought to function by associating with other proteins, including TANK and NEMO. TFG was first identified as a partner of NTRK1 and is involved in generating the thyroid TRK-T3 oncogene, as well as oncogenic rearrangements with ALK in anaplastic lymphoma and NOR1 in mixoid chondrosarcoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein TFG; TRK-fused gene protein; TRKT3 oncogene
Gene Aliases: HMSNP; SPG57; TF6; TFG; TRKT3
UniProt ID: (Human) Q92734
Entrez Gene ID: (Human) 10342
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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