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Product Details
PA5-54935
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TYW2. Recombinant protein control fragment (Product #RP-93938).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2649155
Product Specific Information
Immunogen sequence: WFTQRYREYL QRQKLFDTQH RVEKMPDGSV ALPVLGETLP EQHLQELRNR VAPGSPCMLT QLPDPVPSKR AQGCSPAQKL CLEVSRWVE
Highest antigen sequence identity to the following orthologs: Mouse - 72%, Rat - 74%.
Target Information
TYW2, also known as TRM12, is an enzyme that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW2 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW2 was found to be amplified in 7 of 8 breast cancers cell lines analyzed, and qPCR analysis of 30 breast tumors showed overexpression of TYW2 mRNA of over 2-fold in 26, suggesting that TYW2 may play a role in breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-amino-alpha-carboxypropyl transferase TYW2; homolog of yeast tRNA methyltransferase; tRNA methyltranferase 12 homolog; tRNA wybutosine-synthesizing protein 2 homolog; tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase; tRNA-yW synthesizing protein 2; tRNA-yW-synthesizing protein 2
Gene Aliases: TRM12; TRMT12; TYW2
UniProt ID: (Human) Q53H54
Entrez Gene ID: (Human) 55039
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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