Proteintech

TRPA1 Polyclonal Antibody

TRPA1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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TRPA1 Antibody (19124-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded mouse cerebellum tissue slide using 19124-1-AP (TRPA1 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

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Product Details

19124-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 13 publications 13 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 5 publications 5 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.34 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Target Information

TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction. TRPA1 is a transformation -associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons. Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage. It is now known that TRPA1 protein is also widely expressed outside of the CNS and is dys-regulated during oncogenic transformation. The structure of TRPA1 is highly related to both the protein ankyrin and transmembrane proteins. The specific function of TRPA1 has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes.

Nature aging

Lee HJ,Alirzayeva H,Koyuncu S,Rueber A,Noormohammadi A,Vilchez D

Mon May 01 00:00:00 UTC 2023

L-carnitine alleviates synovitis in knee osteoarthritis by regulating lipid accumulation and mitochondrial function through the AMPK-ACC-CPT1 signaling pathway.

Journal of orthopaedic surgery and research

Liao T,Mei W,Zhang L,Ding L,Yang N,Wang P,Zhang L

Fri May 26 00:00:00 UTC 2023

Water extract of Notopterygium incisum alleviates cold allodynia in neuropathic pain by regulation of TRPA1.

Journal of ethnopharmacology

Ruan Y,Jin X,Ji H,Zhu C,Yang Y,Zhou Y,Yu G,Wang C,Tang Z

Thu Apr 06 00:00:00 UTC 2023

Water extract of Notopterygium incisum alleviates cold allodynia in neuropathic pain by regulation of TRPA1.

Journal of ethnopharmacology

Ruan Y,Jin X,Ji H,Zhu C,Yang Y,Zhou Y,Yu G,Wang C,Tang Z

Thu Apr 06 00:00:00 UTC 2023

Aconitine - A promising candidate for treating cold and mechanical allodynia in cancer induced bone pain.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Jin X,Cheng J,Zhang Q,Ji H,Zhu C,Yang Y,Zhou Y,Yu G,Wang C,Tang Z

Mon May 01 00:00:00 UTC 2023

The Effectiveness of Wogonin on Treating Cough Mice With Mycoplasma Pneumoniae Infection.

Frontiers in molecular biosciences

Liang M,Meng Y,Wang X,Wang L,Tang G,Wang W

Tue Aug 02 00:00:00 UTC 2022

Pharmacogenetic inhibition of lumbosacral sensory neurons alleviates visceral hypersensitivity in a mouse model of chronic pelvic pain.

PloS one

Xie AX,Iguchi N,Clarkson TC,Malykhina AP

Tue Feb 22 00:00:00 UTC 2022

Effect of β-hydroxybutyrate on behavioral alterations, molecular and morphological changes in CNS of multiple sclerosis mouse model.

Frontiers in aging neuroscience

Sun W,Wen M,Liu M,Wang Q,Liu Q,Li L,Siebert HC,Loers G,Zhang R,Zhang N

Thu Dec 22 00:00:00 UTC 2022

Effect of β-hydroxybutyrate on behavioral alterations, molecular and morphological changes in CNS of multiple sclerosis mouse model.

Frontiers in aging neuroscience

Sun W,Wen M,Liu M,Wang Q,Liu Q,Li L,Siebert HC,Loers G,Zhang R,Zhang N

Thu Dec 22 00:00:00 UTC 2022

UVR Promotes Keratinocyte Phagocytosis and Skin Pigmentation Through TRPA1 Channels.

Clinical, cosmetic and investigational dermatology

Liu Y,Li Z,Wu W,Wang Y,Zhao G,Liu Y,Liu J,Song Z

Sat Jul 16 00:00:00 UTC 2022

Inhibition of TRPA1 Attenuates Oxidative Stress-induced Damage After Traumatic Brain Injury via the ERK/AKT Signaling Pathway.

Neuroscience

Yang XJ,Ling S,Zhou ML,Deng HJ,Qi M,Liu XL,Zhen C,Chen YX,Fan XR,Wu ZY,Ma FC,Rong J,Di GF,Jiang XC

Fri Jul 01 00:00:00 UTC 2022

Functional expression of TRPA1 channel, TRPV1 channel and TMEM100 in human odontoblasts.

Journal of molecular histology

Liu Y,Wang Y,Lou Y,Tian W,Que K

Fri Oct 01 00:00:00 UTC 2021

Functional expression of TRPA1 channel, TRPV1 channel and TMEM100 in human odontoblasts.

Journal of molecular histology

Liu Y,Wang Y,Lou Y,Tian W,Que K

Fri Oct 01 00:00:00 UTC 2021

Functional expression of TRPA1 channel, TRPV1 channel and TMEM100 in human odontoblasts.

Journal of molecular histology

Liu Y,Wang Y,Lou Y,Tian W,Que K

Fri Oct 01 00:00:00 UTC 2021

A dual receptors-targeting and size-switchable "cluster bomb" co-loading chemotherapeutic and transient receptor potential ankyrin 1 (TRPA-1) inhibitor for treatment of triple negative breast cancer.

Journal of controlled release : official journal of the Controlled Release Society

Wang Y,Yin S,Mei L,Yang Y,Xu S,He X,Wang M,Li M,Zhang Z,He Q

Sun May 10 00:00:00 UTC 2020

Propofol exerts neuroprotective functions by down-regulating microRNA-19a in glutamic acid-induced PC12 cells.

BioFactors (Oxford, England)

Yu S,Xin W,Jiang Q,Li A

Sun Nov 01 00:00:00 UTC 2020

Propofol exerts neuroprotective functions by down-regulating microRNA-19a in glutamic acid-induced PC12 cells.

BioFactors (Oxford, England)

Yu S,Xin W,Jiang Q,Li A

Sun Nov 01 00:00:00 UTC 2020

Menthol from Mentha piperita Suppresses the Milk Production of Lactating Mammary Epithelial Cells In Vivo and In Vitro.

Molecular nutrition & food research

Suzuki N,Tsugami Y,Wakasa H,Suzuki T,Nishimura T,Kobayashi K

Sat Nov 14 00:00:00 UTC 2020

Menthol from Mentha piperita Suppresses the Milk Production of Lactating Mammary Epithelial Cells In Vivo and In Vitro.

Molecular nutrition & food research

Suzuki N,Tsugami Y,Wakasa H,Suzuki T,Nishimura T,Kobayashi K

Sat Nov 14 00:00:00 UTC 2020

Liquiritin, a novel inhibitor of TRPV1 and TRPA1, protects against LPS-induced acute lung injury.

Cell calcium

Liu Z,Wang P,Lu S,Guo R,Gao W,Tong H,Yin Y,Han X,Liu T,Chen X,Zhu MX,Yang Z

Tue Apr 28 00:00:00 UTC 2020

Cannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts.

Cell death & disease

Lowin T,Tingting R,Zurmahr J,Classen T,Schneider M,Pongratz G

Tue Sep 01 00:00:00 UTC 2020

Transient receptor potential ankyrin 1 (TRPA1) positively regulates imiquimod-induced, psoriasiform dermal inflammation in mice.

Journal of cellular and molecular medicine

Zhou Y,Han D,Follansbee T,Wu X,Yu S,Wang B,Shi Z,Domocos DT,Carstens M,Carstens E,Hwang ST

Mon Jul 01 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: ANKTM1; ankyrin-like with transmembrane domains 1; Ankyrin-like with transmembrane domains protein 1; nompC; p120; Transformation-sensitive protein p120; Transient receptor potential cation channel subfamily A member 1; transient receptor potential cation channel, subfamily A, member 1; TRPA-1; Wasabi receptor

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Gene Aliases: ANKTM1; FEPS; TRPA1; TRPA1b

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UniProt ID: (Human) O75762, (Mouse) Q8BLA8

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Entrez Gene ID: (Human) 8989, (Mouse) 277328

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Function(s)

calcium channel activity channel activity calcium-release channel activity temperature-gated cation channel activity ion channel activity protein binding

Process(es)

ion transport cell surface receptor signaling pathway response to cold response to organic substance response to organic cyclic compound sensory perception of pain response to drug response to hydrogen peroxide response to pain thermoception detection of mechanical stimulus involved in sensory perception of pain detection of chemical stimulus involved in sensory perception of pain release of sequestered calcium ion into cytosol protein homotetramerization calcium ion transmembrane transport transport calcium ion transport ion transmembrane transport response to stimulus

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TRPA1 Polyclonal Antibody

TRPA1 Antibody (19124-1-AP) in IHC (P)

Product Details

19124-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Target Information

Bioinformatics

Performance Guarantee

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