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TRPA1 Polyclonal Antibody
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Product Details
OST00289W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Sheep
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 1050-1120 of rat TRPA1 conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in mouse.
Specificity of this antibody: TRPA1.
Target Information
TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction. TRPA1 is a transformation -associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons. Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage. It is now known that TRPA1 protein is also widely expressed outside of the CNS and is dys-regulated during oncogenic transformation. The structure of TRPA1 is highly related to both the protein ankyrin and transmembrane proteins. The specific function of TRPA1 has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ANKTM1; Ankyrin-like with transmembrane domains protein 1; nompC; Transient receptor potential cation channel subfamily A member 1; TRPA-1; Wasabi receptor
Gene Aliases: Anktm1; Trpa1; TRPA1b
UniProt ID: (Mouse) Q8BLA8, (Rat) Q6RI86
Entrez Gene ID: (Mouse) 277328, (Rat) 312896
transport
ion transport
calcium ion transport
cell surface receptor signaling pathway
response to cold
response to organic substance
response to organic cyclic compound
sensory perception of pain
ion transmembrane transport
response to drug
response to hydrogen peroxide
response to pain
response to stimulus
thermoception
detection of mechanical stimulus involved in sensory perception of pain
detection of chemical stimulus involved in sensory perception of pain
protein homotetramerization
calcium ion transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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