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Alomone Labs, LTD
TRPA1 (extracellular) Polyclonal Antibody
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FIGURE: 1 / 5
TRPA1 (extracellular) Antibody (ACC-037-200UL) in ICC/IF
Expression of TRPA1 in rat PC12 cells - Cell surface detection of TRPA1 in intact living rat PC12 cells. A. Extracellular staining of cells using Anti-TRPA1 (extracellular) Antibody (#ACC-037), (1:50) followed by goat Anti-rabbit-AlexaFluor-594 secondary Antibody (red). B. Live view of the cells. C. Merged image of A and B.
Product Details
ACC-037-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)NSTGIINETSDHSE,corresponding to amino acid residues 747-760 of human TRPA1, 1st extracellular loop
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction. TRPA1 is a transformation -associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons. Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage. It is now known that TRPA1 protein is also widely expressed outside of the CNS and is dys-regulated during oncogenic transformation. The structure of TRPA1 is highly related to both the protein ankyrin and transmembrane proteins. The specific function of TRPA1 has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ANKTM1; ankyrin-like with transmembrane domains 1; Ankyrin-like with transmembrane domains protein 1; nompC; p120; Transformation-sensitive protein p120; Transient receptor potential cation channel subfamily A member 1; transient receptor potential cation channel, subfamily A, member 1; TRPA-1; Wasabi receptor
Gene Aliases: ANKTM1; FEPS; TRPA1; TRPA1b
UniProt ID: (Human) O75762, (Mouse) Q8BLA8, (Rat) Q6RI86
Entrez Gene ID: (Human) 8989, (Mouse) 277328, (Rat) 312896
ion transport
cell surface receptor signaling pathway
response to cold
response to organic substance
response to organic cyclic compound
sensory perception of pain
response to drug
response to hydrogen peroxide
response to pain
thermoception
detection of mechanical stimulus involved in sensory perception of pain
detection of chemical stimulus involved in sensory perception of pain
release of sequestered calcium ion into cytosol
protein homotetramerization
calcium ion transmembrane transport
transport
calcium ion transport
ion transmembrane transport
response to stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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